Department of Organic Chemistry, Faculty of Science, University of Yaoundé I , Yaoundé , Cameroon.
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz , Mainz , Germany.
Nat Prod Res. 2019 Dec;33(24):3521-3526. doi: 10.1080/14786419.2018.1486312. Epub 2018 Jun 25.
The chemical investigation of the leaves and stem bark of (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A together with fifteen known compounds. Their structures were established from spectral , mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound and the analogues as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue compound as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
对（豆科）的叶和茎皮的化学研究导致分离出一种新的齐墩果烷型三萜皂苷，命名为多刺苷 A ，以及十五种已知化合物。它们的结构是根据光谱，主要是 HRESIMS、1D NMR 和 2D NMR，并与文献数据进行比较而确定的。在包括敏感和耐药表型的 9 种癌细胞系中，测定了化合物 和类似物 以及阿霉素的细胞毒性。与类似物 不同，化合物 和阿霉素在所有 9 种测试的癌细胞系中均显示出细胞毒性作用，IC 值范围为 8.90 μM（对 CCRF-CEM 白血病细胞）至 35.21 μM（对 HepG2 肝癌细胞），化合物 的 IC 值为 0.02 μM（对 CCRF-CEM 白血病细胞）至 66.83 μM（对 CEM/ADR5000 白血病细胞）。
