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人类巨细胞病毒中与禽逆转录病毒癌基因v-myc杂交的序列富含鸟嘌呤和胞嘧啶，且不与人类c-myc基因杂交。

Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene.

作者信息

Rasmussen R D, Staprans S I, Shaw S B, Spector D H

出版信息

Mol Cell Biol. 1985 Jun;5(6):1525-30. doi: 10.1128/mcb.5.6.1525-1530.1985.

DOI:10.1128/mcb.5.6.1525-1530.1985
PMID:2993868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366886/
Abstract

The degree of relatedness between previously identified cross-hybridizing regions within human cytomegalovirus strain AD169 and the avian retrovirus oncogene v-myc were investigated by nucleotide sequence comparison. We found that the homologous regions between the human cytomegalovirus genome and v-myc are limited to short G + C-rich regions in each genome and that the human cytomegalovirus genome shares little or no homology with the human c-myc gene.

摘要

通过核苷酸序列比较，研究了人巨细胞病毒AD169株中先前鉴定的交叉杂交区域与禽逆转录病毒癌基因v-myc之间的相关性。我们发现，人巨细胞病毒基因组与v-myc之间的同源区域仅限于每个基因组中的短G + C富集区域，并且人巨细胞病毒基因组与人类c-myc基因几乎没有或没有同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b23/366886/e6fc73bda22c/molcellb00102-0338-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b23/366886/e6fc73bda22c/molcellb00102-0338-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b23/366886/e6fc73bda22c/molcellb00102-0338-a.jpg

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1
Sequences in human cytomegalovirus which hybridize with the avian retrovirus oncogene v-myc are G + C rich and do not hybridize with the human c-myc gene.人类巨细胞病毒中与禽逆转录病毒癌基因v-myc杂交的序列富含鸟嘌呤和胞嘧啶，且不与人类c-myc基因杂交。
Mol Cell Biol. 1985 Jun;5(6):1525-30. doi: 10.1128/mcb.5.6.1525-1530.1985.
2
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Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.根据热变性温度确定脱氧核糖核酸的碱基组成
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Human cytomegalovirus (strain AD169) contains sequences related to the avian retrovirus oncogene v-myc.
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Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product.对人类c-myc基因座、鸡同源物以及髓细胞瘤病毒MC29转化基因的核苷酸序列分析揭示了一种高度保守的基因产物。
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