School of Psychology, Shaanxi Normal University, Xi'an, China.
Soc Cogn Affect Neurosci. 2019 Mar 5;14(3):319-327. doi: 10.1093/scan/nsz008.
Social well-being reflects the perception of one's social functioning, which plays an important role in physical and psychological health. However, the exact neuroanatomical substrate for social well-being remains unclear. To address the issue, we employed the voxel-based morphometry method to probe the neuroanatomical basis of individual variation in social well-being in young healthy adults (n = 136). The results revealed a significant negative association between social well-being and regional gray matter density (rGMD) in an anatomical cluster that mainly includes the left orbitofrontal cortex (OFC) that has been involved in emotion regulation and social cognition. Furthermore, a balanced 4-fold cross-validation using the machine learning approach revealed that rGMD in the left OFC could be reliably related to social well-being. More importantly, the multiple mediation analysis revealed that neuroticism and dispositional forgiveness independently mediated the association between rGMD in the left OFC and social well-being. In addition, all these results remained stable when subjective socioeconomic status was controlled. Together, our results provide the initial evidence that the OFC is a neuroanatomical substrate for social well-being and demonstrate that the OFC is a crucial neural site linking neuroticism and dispositional forgiveness to social well-being.
社交幸福感反映了个体对社会功能的感知，它在身心健康中起着重要作用。然而，社交幸福感的确切神经解剖基础仍不清楚。为了解决这个问题，我们采用基于体素的形态测量学方法，探究了年轻健康成年人（n=136）个体社交幸福感差异的神经解剖基础。结果显示，社交幸福感与包括左侧眶额皮层（OFC）在内的解剖学簇中的区域灰质密度（rGMD）呈显著负相关，左侧 OFC 参与情绪调节和社会认知。此外，使用机器学习方法进行的平衡四折交叉验证表明，左侧 OFC 的 rGMD 与社交幸福感之间存在可靠的关联。更重要的是，多重中介分析表明，神经质和倾向宽恕独立中介了左侧 OFC 的 rGMD 与社交幸福感之间的关系。此外，当控制主观社会经济地位时，所有这些结果仍然稳定。总之，我们的研究结果提供了初步证据，表明 OFC 是社交幸福感的神经解剖基础，并表明 OFC 是一个关键的神经部位，将神经质和倾向宽恕与社交幸福感联系起来。
