Radboud University.
Newcastle University.
Child Dev. 2018 Sep;89(5):1504-1518. doi: 10.1111/cdev.13108. Epub 2018 Jun 26.
In the last decades, developmental origins of health and disease (DOHaD) has emerged as a central framework for studying early-life effects, that is, the impact of fetal and early postnatal experience on adult functioning. Apace with empirical progress, theoreticians have built mathematical models that provide novel insights for DOHaD. This article focuses on three of these insights, which show the power of environmental noise (i.e., imperfect indicators of current and future conditions) in shaping development. Such noise can produce: (a) detrimental outcomes even in ontogenetically stable environments, (b) individual differences in sensitive periods, and (c) early-life effects tailored to predicted future somatic states. We argue that these insights extend DOHaD and offer new research directions.
在过去的几十年中，健康与疾病的发育起源（DOHaD）已经成为研究生命早期效应的核心框架，即胎儿和出生后早期经历对成人功能的影响。随着经验的进步，理论家们构建了数学模型，为 DOHaD 提供了新的见解。本文重点介绍了其中三个见解，这些见解展示了环境噪声（即当前和未来条件的不完善指标）在塑造发育中的力量。这种噪声会产生：（a）即使在发育上稳定的环境中也会产生有害的结果，（b）敏感时期的个体差异，以及（c）针对预测的未来躯体状态定制的生命早期效应。我们认为，这些见解扩展了 DOHaD，并提供了新的研究方向。
