Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Inflammopharmacology. 2018 Dec;26(6):1383-1398. doi: 10.1007/s10787-018-0505-x. Epub 2018 Jun 13.
Boswellia dalzielii is a tall tree (more than 13 m high) that produces aromatic white flowers. This plant is commonly used in indigenous medicine across Africa against diarrhea, malaria, vomiting, inflammation and arthritis. The present study focuses on the anti-inflammatory and anti-arthritis potential of methanol extract of Boswellia dalzielii (BDME). Anti-inflammatory activity was evaluated in inflammatory models induced by carrageenan, arachidonic acid, histamine, serotonin, prostaglandin and bradykinin. Anti-arthritis activity was measured using complete Freund's adjuvant model. Intracellular and extracellular ROS production and proliferation of T-cells were evaluated using chemiluminescence and liquid scintillation counter techniques, respectively. TNF-α and IL-1β production were assessed using ELISA and MTT assay performed for cytotoxicity. BDME revealed a significant anti-inflammatory effect by preventing the development of edema caused by carrageenan, arachidonic acid, histamine, serotonin, prostaglandin and bradykinin. For anti-arthritic properties of BDME, the results showed a significant reduction of the joint diameter and a decrease in pain in the treated animals. The extract also showed a noticeable systemic effect, maintaining the values of the evaluated parameters close to normal in treated rats with an inhibition of joint destruction as shown in histopathological analysis. Furthermore, BDME exhibited significant inhibition of extracellular and intracellular ROS production. Still, the extract displayed significant inhibitory activity on T-cell proliferation as well as a reduced production of TNF-α and IL-1β. Boswellia dalzielii could be considered as a promising tract in the prevention and/or management of inflammatory diseases.
没药树是一种高大的树木（超过 13 米高），开芳香的白花。这种植物在非洲各地的传统医学中被广泛用于治疗腹泻、疟疾、呕吐、炎症和关节炎。本研究主要关注没药树甲醇提取物（BDME）的抗炎和抗关节炎潜力。通过角叉菜胶、花生四烯酸、组胺、血清素、前列腺素和缓激肽诱导的炎症模型评估抗炎活性。使用完全弗氏佐剂模型测量抗关节炎活性。通过化学发光和液体闪烁计数器技术分别评估细胞内和细胞外 ROS 产生和 T 细胞增殖。使用 ELISA 和 MTT 测定法评估 TNF-α 和 IL-1β 的产生以进行细胞毒性测定。BDME 通过防止角叉菜胶、花生四烯酸、组胺、血清素、前列腺素和缓激肽引起的水肿发展，显示出显著的抗炎作用。对于 BDME 的抗关节炎特性，结果表明关节直径显著减小，并且治疗动物的疼痛减轻。该提取物还表现出明显的全身作用，使所评估参数的值在治疗大鼠中接近正常，在组织病理学分析中显示出对关节破坏的抑制作用。此外，BDME 表现出对细胞外和细胞内 ROS 产生的显著抑制作用。然而，该提取物对 T 细胞增殖具有显著的抑制活性，并且 TNF-α和 IL-1β 的产生减少。没药树可被视为预防和/或管理炎症性疾病的有前途的方法。
