母亲怀孕期间饮酒与后代自闭症谱系障碍风险：千禧年队列研究的回顾性分析。
Maternal Alcohol Consumption During Pregnancy and the Risk of Autism Spectrum Disorders in Offspring: A Retrospective Analysis of the Millennium Cohort Study.
机构信息
School of Medicine, University College Cork, Cork, Ireland.
The Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Wilton, Ireland.
出版信息
J Autism Dev Disord. 2018 Nov;48(11):3773-3782. doi: 10.1007/s10803-018-3626-6.
Abstract
The objective of this retrospective analysis of the longitudinal Millennium Cohort Study was to examine whether maternal alcohol consumption in pregnancy (MACP) is associated with the development of childhood autism spectrum disorders (ASD). Data on MACP and ASD were obtained from parental questionnaires. There were 18,168 singleton mother-child pairs with data on MACP, and 12,595 answered the question on ASD when the children were 11 years old. No statistically significant association was found between MACP and ASD for light (OR 0.78, 95% CI 0.48-1.29), moderate (OR 0.89, 95% CI 0.35-2.27), or heavy (OR 1.54, 95% CI 0.56-4.21) MACP. Alcohol consumption during pregnancy was not associated with the risk of developing ASD in this study cohort.
摘要
这项对纵向千年队列研究的回顾性分析的目的是检验母亲怀孕期间饮酒（MACP）是否与儿童自闭症谱系障碍（ASD）的发展有关。MACP 和 ASD 数据来自父母问卷。共有 18168 对单胎母婴对有 MACP 数据，当孩子 11 岁时，有 12595 对回答了关于 ASD 的问题。MACP 与 ASD 之间没有统计学显著关联，无论是轻度（OR 0.78，95%CI 0.48-1.29）、中度（OR 0.89，95%CI 0.35-2.27）还是重度（OR 1.54，95%CI 0.56-4.21）。在本研究队列中，怀孕期间饮酒与 ASD 发病风险无关。
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