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急性缺血性卒中作为斯坦福A型急性主动脉夹层的并发症:综述及紧急诊断的临床建议

Acute ischemic stroke as a complication of Stanford type A acute aortic dissection: a review and proposed clinical recommendations for urgent diagnosis.

作者信息

Koga Masatoshi, Iguchi Yasuyuki, Ohara Tomoyuki, Tahara Yoshio, Fukuda Tetsuya, Noguchi Teruo, Matsuda Hitoshi, Minatoya Kenji, Nagatsuka Kazuyuki, Toyoda Kazunori

机构信息

Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan.

Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2018 Aug;66(8):439-445. doi: 10.1007/s11748-018-0956-4. Epub 2018 Jun 13.

DOI:10.1007/s11748-018-0956-4
PMID:29948797
Abstract

BACKGROUND

Stanford type A acute aortic dissection requires emergency surgery. Because patients with ischemic stroke as a complication of Stanford type A acute aortic dissection do not often complain of chest or back pain, probably due to consciousness disturbance, amnesia, or aphasia, a fatal course following inappropriate intravenous rt-PA therapy and delay of appropriate surgical treatment sometimes occur.

REVIEW AND PROPOSED RECOMMENDATIONS

When treating any suspected stroke patients, emergency services and initial urgent care doctors should always suspect aortic dissection. Even in the absence of chest or back pain, the initial urgent care doctor needs to immediately perform chest contrast CT if suspecting aortic dissection from blood pressure laterality or upper mediastinal widening on chest X-ray. Whenever aortic dissection cannot be ruled out from initial clinical information, the initial urgent care doctor should evaluate the common carotid artery (CCA). Dissection extension to the CCA or flow abnormality of the CCA is often detected if aortic dissection is a cause of ischemic stroke or transient ischemic attack. Head CT or MRI including vascular imaging is preferable. D-dimer should be measured in hospitals where available. As soon as aortic dissection is identified, the initial urgent care doctor needs to consult with cardiovascular surgeons or cardiologists for appropriate treatment.

摘要

背景

A型主动脉夹层急症需要紧急手术。由于A型主动脉夹层并发缺血性卒中的患者常因意识障碍、失忆或失语而无胸痛或背痛主诉,不适当的静脉注射重组组织型纤溶酶原激活剂(rt-PA)治疗及适当手术治疗延误有时会导致致命后果。

综述及建议

在治疗任何疑似卒中患者时,急救服务人员及首诊急诊医生均应始终怀疑主动脉夹层。即使无胸痛或背痛,若根据胸部X线检查发现血压差异或上纵隔增宽怀疑主动脉夹层,首诊急诊医生也需立即进行胸部增强CT检查。若根据初始临床信息不能排除主动脉夹层,首诊急诊医生应评估颈总动脉(CCA)。若主动脉夹层是缺血性卒中和短暂性脑缺血发作的病因,常可检测到夹层延伸至CCA或CCA血流异常。最好进行包括血管成像的头颅CT或MRI检查。有条件的医院应检测D-二聚体。一旦确诊主动脉夹层,首诊急诊医生需咨询心血管外科医生或心脏病专家以进行适当治疗。

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