Polystim Neurotech Laboratory, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, H3T 1J4, Canada.
Department of Neurosurgery, University of Montreal Medical Center, Montreal, H2X 0C1, Canada.
Nanomedicine (Lond). 2018 Jun;13(11):1385-1400. doi: 10.2217/nnm-2018-0021.
Superparamagnetic iron oxide nanoparticles (SPIONs) consist of nanosized metallic-based particles with unique magnetic properties. Their potential in both diagnostic and therapeutic applications in the CNS is at the source of an expanding body of the literature in recent years. Colloidal stability of nanoparticles represents their ability to resist aggregation and is a central aspect for the use of SPION in biological environment such as the CNS. This review gives a comprehensive update of the recent developments and knowledge on the determinants of colloidal stability of SPIONs in the CNS. Factors leading to aggregate formation and the repercussions of colloidal instability of SPION are reviewed in detail pertaining to their use in the CNS.
超顺磁性氧化铁纳米颗粒（SPIONs）由具有独特磁性的纳米级金属颗粒组成。近年来，它们在中枢神经系统的诊断和治疗应用方面的潜力引发了大量文献的出现。纳米颗粒的胶体稳定性代表了它们抵抗聚集的能力，这是 SPION 在中枢神经系统等生物环境中应用的一个核心方面。本文综述了近年来关于 SPION 在中枢神经系统中胶体稳定性决定因素的最新进展和知识。详细回顾了导致聚集形成的因素和胶体不稳定性的影响，以及它们在中枢神经系统中的应用。
