细胞应激反应中的适应性和失调性线粒体动态变化。
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.
机构信息
Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Division of Behavioral Medicine, Departments of Psychiatry and Neurology, The Merritt Center, Columbia Translational Neuroscience Initiative, Columbia Aging Center, Columbia University Medical Center, New York, NY, USA.
出版信息
Nat Cell Biol. 2018 Jul;20(7):755-765. doi: 10.1038/s41556-018-0133-0. Epub 2018 Jun 27.
Abstract
Mitochondria sense and respond to many stressors and can support either cell survival or death through energy production and signaling pathways. Mitochondrial responses depend on fusion-fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, including with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.
摘要
线粒体能够感知和应对多种应激源，并通过能量产生和信号通路来支持细胞的存活或死亡。线粒体的反应取决于融合-分裂动力学，该动力学可以稀释和隔离受损的线粒体。线粒体的运动和细胞器间的相互作用，包括与内质网的相互作用，也在细胞对压力的适应中发挥作用。在这篇综述中，我们讨论了应激源如何影响这些成分，以及它们如何导致导致疾病的复杂适应和病理反应。
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