Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Oxid Med Cell Longev. 2018 May 21;2018:9303094. doi: 10.1155/2018/9303094. eCollection 2018.
Oral cancer is the fifth leading cause of cancer death in Taiwan, and the prevalence of metabolic syndrome (MS) has also increased globally. The purpose of this study was to investigate the correlations between the components of MS and oxidative stress and inflammation in patients with oral cancer based on their areca-nut-chewing habits. Two hundred patients diagnosed with oral cancer were recruited, and metabolic parameters, oxidative stress, antioxidant enzyme activities, and inflammatory markers were measured. 63% of the subjects have concomitant MS. Subjects who had an areca-nut-chewing habit had significantly higher levels of fasting glucose ( = 0.04), oxidative stress ( = 0.02), and inflammatory markers ( = 0.02) than those who never chewed. High-density lipoprotein-cholesterol level ( = 0.03) and superoxidase dismutase activity ( = 0.02) were significantly lower in individuals who had chewed or were currently chewers. Areca-nut-chewing habit was associated with the increased risks for MS and hypertriglyceridemia; the components of MS were positively correlated with oxidative stress and inflammation. In conclusion, patients with oral cancer who had an areca-nut-chewing habit exhibited higher levels of oxidative stress and inflammation, which might be related to an increased risk of MS.
口腔癌是台湾地区第五大癌症死因，而代谢综合征（MS）的患病率也在全球范围内上升。本研究旨在根据嚼食槟榔的习惯，探讨口腔癌患者 MS 各组分与氧化应激和炎症之间的相关性。我们招募了 200 名被诊断为口腔癌的患者，并测量了代谢参数、氧化应激、抗氧化酶活性和炎症标志物。63%的研究对象同时患有 MS。与从不嚼食槟榔的患者相比，有嚼食槟榔习惯的患者空腹血糖（ = 0.04）、氧化应激（ = 0.02）和炎症标志物（ = 0.02）水平显著升高。高密度脂蛋白胆固醇水平（ = 0.03）和超氧化物歧化酶活性（ = 0.02）在嚼食或正在嚼食的个体中显著降低。嚼食槟榔与 MS 和高三酰甘油血症的风险增加有关；MS 的各组分与氧化应激和炎症呈正相关。总之，有嚼食槟榔习惯的口腔癌患者表现出更高水平的氧化应激和炎症，这可能与 MS 风险增加有关。
