Institute of Pharmaceutical Research, GLA University, NH-2, Mathura-Delhi Road, Mathura (U.P.), 281 406. India.
Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.), 470 003. India.
Curr Mol Med. 2017;17(5):321-340. doi: 10.2174/1566524018666171205113329.
Over a few decades a strong interlink between oxidative damage and cancer has been investigated by various scientists across the world on the basis of epidemiological observations of the effects of fruits and vegetables used in the diet for cancer patients. Primarily, Vitamin C, Vitamin D and Vitamin E are reported to be involved in the amelioration of side effects which occur in chemotherapy and radiation therapy of lungs, stomach, prostate, colorectal, gastric head and neck cancers. The vitamins acting as antioxidant adjuvants are found to have apoptotic and antiangiogenesis potential as well as inhibitory effects against metastasis in cancer cells. This chapter explicitly discusses the key aspects concerned with the vitamins in relation to cancer prevention and treatment. It describes vitamins and their natural resources, role of vitamins in the body, and vitamins as prime ingredients in the diet and their effects on cancer biology with reference to recent research reports. Moreover, this paper also includes the emerging potential of pharmaceutical advances to enhance bioavailability of the vitamins to cancer patients with improved safety and efficacy. Clinicians and researchers must mull over the nutritional requirements of individual cancer patient so as to treat cancer and increase life expectancy.
几十年来，世界各地的科学家们基于对癌症患者饮食中水果和蔬菜的影响的流行病学观察，对氧化损伤与癌症之间的紧密联系进行了广泛研究。据报道，维生素 C、维生素 D 和维生素 E 主要参与改善肺癌、胃癌、前列腺癌、结直肠癌、胃头颈部癌症的化疗和放疗中出现的副作用。作为抗氧化辅助剂的维生素被发现具有凋亡和抗血管生成的潜力，以及对癌细胞转移的抑制作用。本章明确讨论了与癌症预防和治疗相关的维生素的关键方面。它描述了维生素及其天然资源、维生素在体内的作用、维生素作为饮食中的主要成分及其对癌症生物学的影响，并参考了最近的研究报告。此外，本文还包括了制药领域的新进展，以提高癌症患者对维生素的生物利用度，提高安全性和疗效。临床医生和研究人员必须考虑到每个癌症患者的营养需求，以便治疗癌症并延长预期寿命。
