血清脂质运载蛋白2水平升高与2型糖尿病患者的血糖和骨代谢指标均相关。
Elevated serum lipocalin 2 levels are associated with indexes of both glucose and bone metabolism in type 2 diabetes mellitus.
作者信息
Wang Wei, Ye Shandong, Qian Liting, Xing Yan, Ren An, Chen Chao, Li Sumei, Xu Jiang, Liu Qian, Dong Lin, Xiao Chunchun, Zhou Wan
出版信息
Endokrynol Pol. 2018;69(3):276-282. doi: 10.5603/EP.a2018.0030.
INTRODUCTION
The role of lipocalin 2 (LCN2) in type 2 diabetes mellitus (T2DM) needs to be fully elucidated. Moreover, bone has been demonstrated to modulate glucose metabolism via LCN2. We thus performed this study to investigate the associations of LCN2 with indexes of glucose metabolism in T2DM. The associations of LCN2 with bone metabolism were examined concurrently.
MATERIAL AND METHODS
Total 288 Chinese Han subjects entered in this study including 146 patients with T2DM and 142 subjects with normal glucose tolerance. Insulin resistance was assessed by HOMA-IR and.
引言
脂钙素2（LCN2）在2型糖尿病（T2DM）中的作用尚需充分阐明。此外，已有研究表明骨骼可通过LCN2调节葡萄糖代谢。因此，我们开展了本研究，以探讨LCN2与T2DM患者葡萄糖代谢指标之间的关联。同时还检测了LCN2与骨代谢之间的关联。
材料与方法
本研究共纳入288名中国汉族受试者，其中包括146例T2DM患者和142例糖耐量正常者。采用稳态模型评估法胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗情况，并且……
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