• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血清脂质运载蛋白2水平升高与2型糖尿病患者的血糖和骨代谢指标均相关。

Elevated serum lipocalin 2 levels are associated with indexes of both glucose and bone metabolism in type 2 diabetes mellitus.

作者信息

Wang Wei, Ye Shandong, Qian Liting, Xing Yan, Ren An, Chen Chao, Li Sumei, Xu Jiang, Liu Qian, Dong Lin, Xiao Chunchun, Zhou Wan

出版信息

Endokrynol Pol. 2018;69(3):276-282. doi: 10.5603/EP.a2018.0030.

DOI:10.5603/EP.a2018.0030
PMID:29952418
Abstract

INTRODUCTION

The role of lipocalin 2 (LCN2) in type 2 diabetes mellitus (T2DM) needs to be fully elucidated. Moreover, bone has been demonstrated to modulate glucose metabolism via LCN2. We thus performed this study to investigate the associations of LCN2 with indexes of glucose metabolism in T2DM. The associations of LCN2 with bone metabolism were examined concurrently.

MATERIAL AND METHODS

Total 288 Chinese Han subjects entered in this study including 146 patients with T2DM and 142 subjects with normal glucose tolerance. Insulin resistance was assessed by HOMA-IR and.

摘要

引言

脂钙素2（LCN2）在2型糖尿病（T2DM）中的作用尚需充分阐明。此外，已有研究表明骨骼可通过LCN2调节葡萄糖代谢。因此，我们开展了本研究，以探讨LCN2与T2DM患者葡萄糖代谢指标之间的关联。同时还检测了LCN2与骨代谢之间的关联。

材料与方法

本研究共纳入288名中国汉族受试者，其中包括146例T2DM患者和142例糖耐量正常者。采用稳态模型评估法胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗情况，并且……

相似文献

1
Elevated serum lipocalin 2 levels are associated with indexes of both glucose and bone metabolism in type 2 diabetes mellitus.血清脂质运载蛋白2水平升高与2型糖尿病患者的血糖和骨代谢指标均相关。
Endokrynol Pol. 2018;69(3):276-282. doi: 10.5603/EP.a2018.0030.
2
Associations between circulating bone-derived hormones lipocalin 2, osteocalcin, and glucose metabolism in acromegaly.肢端肥大症患者循环骨源激素脂联素 2、骨钙素与糖代谢的相关性研究。
J Endocrinol Invest. 2020 Sep;43(9):1309-1316. doi: 10.1007/s40618-020-01221-9. Epub 2020 Mar 20.
3
The relationship among serum lipocalin 2, bone turnover markers, and bone mineral density in outpatient women.门诊女性血清脂联素 2、骨转换标志物与骨密度的关系。
Endocrine. 2018 Feb;59(2):304-310. doi: 10.1007/s12020-017-1504-1. Epub 2018 Jan 2.
4
Association between serum osteocalcin and glucose/lipid metabolism in Chinese Han and Uygur populations with type 2 diabetes mellitus in Xinjiang: two cross-sectional studies.新疆汉族和维吾尔族2型糖尿病患者血清骨钙素与糖脂代谢的关系：两项横断面研究
Lipids Health Dis. 2017 Jul 21;16(1):139. doi: 10.1186/s12944-017-0512-8.
5
Cardiometabolic associations of circulating Lipocalin-2 in adults with varying degrees of adiposity and insulin resistance.循环脂联素 2 与不同程度肥胖和胰岛素抵抗成人的心脏代谢关联。
Arch Biochem Biophys. 2022 Mar 15;717:109138. doi: 10.1016/j.abb.2022.109138. Epub 2022 Jan 26.
6
Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people.中国人脂联素-2、葡萄糖代谢与慢性低度全身炎症。
Cardiovasc Diabetol. 2012 Jan 31;11:11. doi: 10.1186/1475-2840-11-11.
7
Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway.袖状胃切除术通过叉头框 O1（FoxO1）/脂联素 2（LCN2）通路对糖代谢的影响。
Med Sci Monit. 2020 Aug 26;26:e927458. doi: 10.12659/MSM.927458.
8
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes.脂联素-2 可逆转肥胖和糖尿病的代谢紊乱。
J Exp Med. 2020 Oct 5;217(10). doi: 10.1084/jem.20191261.
9
[Serum retinol binding protein 4 and bone metabolism in patients with type 2 diabetes].2型糖尿病患者血清视黄醇结合蛋白4与骨代谢
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Feb;37(2):197-202. doi: 10.3969/j.issn.1672-7347.2012.02.015.
10
Increased lipocalin 2 levels in adolescents with type 2 diabetes mellitus.青少年 2 型糖尿病患者脂联素 2 水平升高。
J Pediatr Endocrinol Metab. 2021 Jun 14;34(8):979-985. doi: 10.1515/jpem-2021-0216. Print 2021 Aug 26.

引用本文的文献

1
Interrelationships among metabolic syndrome, bone-derived cytokines, and the most common metabolic syndrome-related diseases negatively affecting bone quality.代谢综合征、骨源性细胞因子以及最常见的与代谢综合征相关的、对骨质量产生负面影响的疾病之间的相互关系。
Diabetol Metab Syndr. 2024 Sep 6;16(1):217. doi: 10.1186/s13098-024-01440-7.
2
Lipocalin-2 as a fundamental protein in type 2 diabetes and periodontitis in mice.脂质运载蛋白-2作为小鼠2型糖尿病和牙周炎中的一种基础蛋白。
J Periodontol. 2025 Apr;96(4):369-382. doi: 10.1002/JPER.24-0215. Epub 2024 Aug 27.
3
The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease.
骨源性激素在糖尿病及其肾脏并发症中的新作用。
Front Endocrinol (Lausanne). 2022 Jul 11;13:938830. doi: 10.3389/fendo.2022.938830. eCollection 2022.
4
Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se.血浆里的2-微球蛋白和脂联素受肥胖影响，而非2型糖尿病本身。
Diabetes Metab Syndr Obes. 2021 Nov 16;14:4547-4556. doi: 10.2147/DMSO.S338254. eCollection 2021.
5
The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes.2型糖尿病患者血清2-微球蛋白水平升高与糖尿病周围神经病变的关系。
Endocr Connect. 2021 Nov 3;10(11):1403-1409. doi: 10.1530/EC-21-0290.
6
Endocrine role of bone in the regulation of energy metabolism.骨骼在能量代谢调节中的内分泌作用。
Bone Res. 2021 May 20;9(1):25. doi: 10.1038/s41413-021-00142-4.
7
Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy.脂联素 2 作为中心性浆液性脉络膜视网膜病变的潜在系统生物标志物。
Sci Rep. 2020 Nov 19;10(1):20175. doi: 10.1038/s41598-020-77202-y.
8
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes.脂联素-2 可逆转肥胖和糖尿病的代谢紊乱。
J Exp Med. 2020 Oct 5;217(10). doi: 10.1084/jem.20191261.