一类独特的内皮细胞多肽促有丝分裂原：牛内皮细胞生长因子、脑源性酸性成纤维细胞生长因子和眼源性生长因子-II的抗原性及受体交叉反应性
A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II.
作者信息
Schreiber A B, Kenney J, Kowalski J, Thomas K A, Gimenez-Gallego G, Rios-Candelore M, Di Salvo J, Barritault D, Courty J, Courtois Y, Moenner M, Loret C, Burgess W H, Mehlman T, Friesel R, Johnson W, Maciag T
出版信息
J Cell Biol. 1985 Oct;101(4):1623-6. doi: 10.1083/jcb.101.4.1623.
Abstract
Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [125I]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pI brain-derived fibroblast growth factor (acidic FGF) and bovine eye-derived growth factor-II [EDGF-II). We observed that acidic FGF and EDGF-II are recognized by anti-ECGF monoclonal antibodies and compete with [125I] ECGF for receptor occupancy. Furthermore, the biological activity of ECGF, acidic FGF, and EDGF-II is potentiated by the glycosaminoglycan, heparin. These results argue that ECGF, acidic FGF, and EDGF-II belong to a common family of polypeptide growth factors.
摘要
牛脑、下丘脑、垂体和视网膜含有对内皮细胞有强大作用的阴离子多肽促细胞分裂剂。使用抗牛内皮细胞生长因子（ECGF）的鼠单克隆抗体进行免疫测定，以及使用[125I]ECGF进行放射受体测定，以确定ECGF与牛酸性pI脑源性成纤维细胞生长因子（酸性FGF）和牛眼源性生长因子-II [EDGF-II]的交叉反应性。我们观察到酸性FGF和EDGF-II可被抗ECGF单克隆抗体识别，并与[125I]ECGF竞争受体结合。此外，糖胺聚糖肝素可增强ECGF、酸性FGF和EDGF-II的生物活性。这些结果表明，ECGF、酸性FGF和EDGF-II属于一个共同的多肽生长因子家族。
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