内皮细胞生长因子β是内皮细胞生长因子α和酸性成纤维细胞生长因子两者的前体的结构证据。
Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor.
作者信息
Burgess W H, Mehlman T, Marshak D R, Fraser B A, Maciag T
出版信息
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7216-20. doi: 10.1073/pnas.83.19.7216.
Abstract
Two endothelial cell growth factors (ECGF) have been purified from bovine brain and termed alpha- and beta-ECGF [Burgess, W. H., Mehlman, T., Friesel, R., Johnson, W. V. & Maciag, T. (1985) J. Biol. Chem. 260, 11389-11392]. Amino acid sequence analysis indicates that beta-ECGF represents a 20 amino acid amino-terminal extension of alpha-ECGF and a 14 amino acid amino-terminal extension of acidic fibroblast growth factor. These data indicate that both alpha-ECGF and acidic fibroblast growth factor may be derived from beta-ECGF by posttranslational processing. Analysis of the amino-terminal 14 residues of beta-ECGF by fast-atom-bombardment mass spectrometry established the amino acid sequence of this region and the identity of the blocking group at the amino terminus (acetyl).
摘要
已从牛脑中纯化出两种内皮细胞生长因子（ECGF），分别命名为α-ECGF和β-ECGF [伯吉斯，W. H.，梅尔曼，T.，弗里塞尔，R.，约翰逊，W. V. & 马西亚格，T.（1985年）《生物化学杂志》260，11389 - 11392]。氨基酸序列分析表明，β-ECGF代表α-ECGF的20个氨基酸的氨基末端延伸以及酸性成纤维细胞生长因子的14个氨基酸的氨基末端延伸。这些数据表明，α-ECGF和酸性成纤维细胞生长因子可能都是通过翻译后加工从β-ECGF衍生而来。通过快原子轰击质谱法对β-ECGF的氨基末端14个残基进行分析，确定了该区域的氨基酸序列以及氨基末端封闭基团（乙酰基）的身份。
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