Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, China.
Department of Mathematics, College of Science, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay061.
Long non-coding RNAs (lncRNAs) are endogenous molecules longer than 200 nucleotides, and lack coding potential. LncRNAs that interact with microRNAs (miRNAs) are known as a competing endogenous RNAs (ceRNAs) and have the ability to regulate the expression of target genes. The ceRNAs play an important role in the initiation and progression of various cancers. However, until now, there is no a database including a collection of experimentally verified, human ceRNAs. We developed the LncCeRBase database, which encompasses 432 lncRNA-miRNA-mRNA interactions, including 130 lncRNAs, 214 miRNAs and 245 genes from 300 publications. In addition, we compiled the signaling pathways associated with the included lncRNA-miRNA-mRNA interactions as a tool to explore their functions. LncCeRBase is useful for understanding the regulatory mechanisms of lncRNA.Database URL: http://lnccerbase.it1004.com.
长链非编码 RNA（lncRNAs）是长度大于 200 个核苷酸的内源性分子，缺乏编码潜力。与 microRNAs（miRNAs）相互作用的 lncRNAs 被称为竞争性内源 RNA（ceRNAs），具有调节靶基因表达的能力。ceRNAs 在各种癌症的发生和发展中起着重要作用。然而，到目前为止，还没有一个数据库包括经过实验验证的人类 ceRNAs 的集合。我们开发了 LncCeRBase 数据库，其中包含 432 个 lncRNA-miRNA-mRNA 相互作用，包括来自 300 篇出版物的 130 个 lncRNAs、214 个 miRNAs 和 245 个基因。此外，我们还编译了与包含的 lncRNA-miRNA-mRNA 相互作用相关的信号通路，作为探索其功能的工具。LncCeRBase 有助于理解 lncRNA 的调控机制。数据库网址：http://lnccerbase.it1004.com。
