伴发性无晶状体眼的非对称羟氯喹黄斑毒性。
ASYMMETRIC HYDROXYCHLOROQUINE MACULAR TOXICITY WITH APHAKIC FELLOW EYE.
机构信息
Department of Ophthalmology, Melbourne Health, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
出版信息
Retin Cases Brief Rep. 2021 Mar 1;15(2):176-178. doi: 10.1097/ICB.0000000000000750.
BACKGROUND/PURPOSE: Retinal toxicity associated with antimalarial drug use in inflammatory conditions is well described and may be more common than previously recognized. Antimalarial drugs bind to melanin in ocular tissues, particularly the retinal pigment epithelium, but the mechanism of toxicity and its relation to light is unclear.
METHODS
Case report.
RESULTS
A 62-year-old white woman with erosive rheumatoid arthritis developed hydroxychloroquine toxicity in her phakic eye, with her aphakic fellow eye only mildly affected.
CONCLUSION
We report the clinical evaluation of this rare case of asymmetrical hydroxychloroquine retinopathy and present a hypothesis regarding the mechanism of drug toxicity.
背景/目的：在炎症情况下使用抗疟药物会引起视网膜毒性，这种情况已得到充分描述，且可能比之前认为的更为常见。抗疟药物与眼部组织中的黑色素结合，特别是与视网膜色素上皮结合，但毒性的机制及其与光线的关系尚不清楚。
方法
病例报告。
结果
一名 62 岁白人女性患有侵蚀性类风湿关节炎，在其有晶状体眼出现羟氯喹毒性，而无晶状体的对侧眼仅受到轻微影响。
结论
我们报告了这例罕见的不对称羟氯喹性视网膜病变的临床评估，并提出了一个关于药物毒性机制的假说。
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