Myelin Biology Unit, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Viral Pathogens and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.
Sci Rep. 2018 Jul 5;8(1):10166. doi: 10.1038/s41598-018-28257-5.
Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity.
寨卡病毒（ZIKV）是一种神经嗜性病原体，可感染妊娠期间感染的孕妇的发育中的胎儿大脑。除了发育中的中枢神经系统外，最近还表明寨卡病毒能够感染周围神经系统（PNS）的细胞，这突出了其在成人中引起急性周围神经病变的潜力，例如格林-巴利综合征（GBS）。在这里，我们表明，来自干扰素-α/β受体敲除小鼠的有髓背根神经节（DRG）外植体可被寨卡病毒有效感染。病毒复制在周围神经元和有髓鞘施万细胞中均具有细胞病变作用，导致髓鞘破坏。这些结果证实并扩展了先前的观察结果，表明周围神经系统确实是寨卡病毒感染，复制和细胞病变的潜在部位。
