Mostafalu Pooria, Tamayol Ali, Rahimi Rahim, Ochoa Manuel, Khalilpour Akbar, Kiaee Gita, Yazdi Iman K, Bagherifard Sara, Dokmeci Mehmet R, Ziaie Babak, Sonkusale Sameer R, Khademhosseini Ali
Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Small. 2018 Jul 6:e1703509. doi: 10.1002/smll.201703509.
Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to address this unmet medical need is presented. Moreover, a stimuli-responsive drug releasing system comprising of a hydrogel loaded with thermo-responsive drug carriers and an electronically controlled flexible heater is also integrated into the wound dressing to release the drugs on-demand. The dressing is equipped with a microcontroller to process the data measured by the sensors and to program the drug release protocol for individualized treatment. This flexible smart wound dressing has the potential to significantly impact the treatment of chronic wounds.
慢性伤口是一个重大的健康问题，在美国影响着超过2500万人的生活。它们容易受到感染，是全球非创伤性肢体截肢的主要原因。伤口环境是动态的，但通过在适当时间进行治疗可以提高其愈合速度。这种方法需要以闭环方式对伤口环境进行实时监测并按需给药。本文介绍了一种智能自动化的柔性伤口敷料，其将温度和pH传感器集成到柔性绷带上，可实时监测伤口状态，以满足这一未被满足的医疗需求。此外，一种由负载有热响应药物载体的水凝胶和电控柔性加热器组成的刺激响应药物释放系统也集成到伤口敷料中，以按需释放药物。该敷料配备有微控制器，用于处理传感器测量的数据并为个性化治疗制定药物释放方案。这种柔性智能伤口敷料有可能对慢性伤口的治疗产生重大影响。
