Pang Qian, Lou Dong, Li Shijian, Wang Guangming, Qiao Bianbian, Dong Shurong, Ma Lie, Gao Changyou, Wu Zhaohui
MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China.
College of Computer Science and Technology Zhejiang University Hangzhou 310027 China.
Adv Sci (Weinh). 2020 Jan 10;7(6):1902673. doi: 10.1002/advs.201902673. eCollection 2020 Mar.
As the most frequent wound complication, infection has become a major clinical challenge in wound management. To overcome the "Black Box" status of the wound-healing process, next-generation wound dressings with the abilities of real-time monitoring, diagnosis during early stages, and on-demand therapy has attracted considerable attention. Here, by combining the emerging development of bioelectronics, a smart flexible electronics-integrated wound dressing with a double-layer structure, the upper layer of which is polydimethylsiloxane-encapsulated flexible electronics integrated with a temperature sensor and ultraviolet (UV) light-emitting diodes, and the lower layer of which is a UV-responsive antibacterial hydrogel, is designed. This dressing is expected to provide early infection diagnosis via real-time wound-temperature monitoring by the integrated sensor and on-demand infection treatment by the release of antibiotics from the hydrogel by in situ UV irradiation. The integrated system possesses good flexibility, excellent compatibility, and high monitoring sensitivity and durability. Animal experiment results demonstrate that the integrated system is capable of monitoring wound status in real time, detecting bacterial infection and providing effective treatment on the basis of need. This proof-of-concept research holds great promise in developing new strategies to significantly improve wound management and other pathological diagnoses and treatments.
作为最常见的伤口并发症，感染已成为伤口管理中的一项重大临床挑战。为了克服伤口愈合过程的“黑箱”状态，具有实时监测、早期诊断和按需治疗能力的下一代伤口敷料引起了广泛关注。在此，通过结合生物电子学的最新发展，设计了一种具有双层结构的智能柔性电子集成伤口敷料，其上层是集成了温度传感器和紫外线（UV）发光二极管的聚二甲基硅氧烷封装柔性电子器件，下层是紫外线响应抗菌水凝胶。这种敷料有望通过集成传感器实时监测伤口温度来进行早期感染诊断，并通过原位紫外线照射使水凝胶释放抗生素来进行按需感染治疗。该集成系统具有良好的柔韧性、优异的兼容性以及高监测灵敏度和耐久性。动物实验结果表明，该集成系统能够实时监测伤口状态，检测细菌感染并根据需要提供有效治疗。这一概念验证研究在开发显著改善伤口管理及其他病理诊断和治疗的新策略方面具有巨大潜力。
