Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada.
Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC, V8P 5C2, Canada.
Adv Healthc Mater. 2023 Jul;12(18):e2203233. doi: 10.1002/adhm.202203233. Epub 2023 Mar 29.
Managing slow-healing wounds and associated complications is challenging, time-consuming, and expensive. Systematic collection, analysis, and dissemination of correct wound status data are critical for enhancing healing outcomes and reducing complications. However, traditional data collection approaches are often neither accurate nor user-friendly and require diverse skill levels, resulting in the collection of inconsistent and unreliable data. As an advancement to the authors' previously developed hydrogel-based smart wound dressing, here is reported an enhanced integration of drug delivery and sensing (pH and glucose) modules for accelerated treatment and continuous monitoring of cutaneous wounds. In the current study, growth factor delivery modules and an array of colorimetric glucose sensors are incorporated into the dressing to promote wound healing and extend the dressing's utility for diabetic wound treatment. Furthermore, the efficacy of the wound dressing in monitoring infection and supporting wound healing via antibiotic and growth factor delivery is investigated in mice models. The updated dressing reveals excellent healing benefits on non-infected and infected wounds, as well as real-time monitoring and early detection of wound infection.
管理愈合缓慢的伤口和相关并发症具有挑战性，既耗时又昂贵。系统地收集、分析和传播正确的伤口状态数据对于提高愈合效果和减少并发症至关重要。然而，传统的数据收集方法往往既不准确也不便于用户使用，并且需要不同的技能水平，导致收集的数据不一致且不可靠。作为作者之前开发的基于水凝胶的智能伤口敷料的一项进步，这里报告了一种增强的药物输送和传感（pH 和葡萄糖）模块的集成，用于加速治疗和对皮肤伤口的连续监测。在本研究中，将生长因子输送模块和一系列比色葡萄糖传感器整合到敷料中，以促进伤口愈合并延长敷料在糖尿病伤口治疗中的应用。此外，还通过小鼠模型研究了伤口敷料在通过抗生素和生长因子输送监测感染和支持伤口愈合方面的功效。更新后的敷料在非感染和感染伤口上都显示出极好的愈合益处，以及对伤口感染的实时监测和早期检测。
