下丘脑 - 垂体 - 肾上腺轴功能障碍的双相情感障碍患者体内热休克蛋白升高。
Elevated heat shock proteins in bipolar disorder patients with hypothalamic pituitary adrenal axis dysfunction.
作者信息
Cheng Yuhang, Li Zhili, He San, Tian Yujie, He Fan, Li Wenbiao
机构信息
The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College Department of Psychiatry Beijing Anding Hospital, Capital Medical University, Beijing, People's Republic of China.
出版信息
Medicine (Baltimore). 2018 Jul;97(27):e11089. doi: 10.1097/MD.0000000000011089.
BACKGROUND
Heat shock proteins (HSP) might be useful as biomarkers for bipolar disorder (BD) which would be clinically valuable since no reliable biomarker for BD has so far been identified. The purpose of this study was to assess the heat shock proteins CPN10, CPN60, and CPN70 as potential biomarkers of BD.
METHODS
The study included 100 BD patients recruited from a hospital during 2012 and 2013. The study also included 94 healthy controls. Among the BD patients, 33 had abnormal hypothalamic-pituitary-adrenal (HPA) axis activity. Blood samples were obtained from the patients and controls. The chemiluminescence method, mass spectrometry, and flow cytometry were used for analysis.
RESULTS
The BD patients compared with the controls had a significantly lower level of CPN10 and significantly higher levels of CPN60 and CPN70. The BD patients with abnormal HPA axis activity had a significantly lower level of CPN60 compared with the normal HPA axis activity group of BD patients. The CPN60 level significantly inversely correlated with adrenocorticotropic hormone (ACTH) level in patients with bipolar depression and in patients with bipolar hypomania, and CPN70 significantly correlated with ACTH level in patients with bipolar depression and hypomania.
CONCLUSIONS
Our findings suggest that the heat shock proteins CPN10, CPN60, and CPN70 might have potential as biomarkers for BD and CPN60 blood level might distinguish patients with abnormal HPA axis activity from those with normal HPA axis activity.
背景
热休克蛋白（HSP）可能作为双相情感障碍（BD）的生物标志物，鉴于目前尚未确定BD的可靠生物标志物，这在临床上具有重要价值。本研究旨在评估热休克蛋白CPN10、CPN60和CPN70作为BD潜在生物标志物的情况。
方法
该研究纳入了2012年至2013年期间从一家医院招募的100例BD患者。研究还包括94名健康对照者。在BD患者中，33例下丘脑 - 垂体 - 肾上腺（HPA）轴活动异常。从患者和对照者采集血样。采用化学发光法、质谱法和流式细胞术进行分析。
结果
与对照组相比，BD患者的CPN10水平显著降低，CPN60和CPN70水平显著升高。HPA轴活动异常的BD患者与HPA轴活动正常的BD患者组相比，CPN60水平显著降低。在双相抑郁患者和双相轻躁狂患者中，CPN60水平与促肾上腺皮质激素（ACTH）水平显著负相关，在双相抑郁和轻躁狂患者中，CPN70与ACTH水平显著相关。
结论
我们的研究结果表明，热休克蛋白CPN10、CPN60和CPN70可能具有作为BD生物标志物的潜力，CPN60的血液水平可能区分HPA轴活动异常的患者与HPA轴活动正常的患者。
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