无法证实对爱泼斯坦-巴尔病毒DNA转化区域的鉴定。

An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed.

作者信息

Miller G, Sugden B

出版信息

Virology. 1985 Jun;143(2):478-84. doi: 10.1016/0042-6822(85)90387-3.

Abstract

We have analyzed Epstein-Barr viral DNA sequences in two cell lines HI-26-36 and HI-HFX. Stoerker et al. (J. Stoerker, J.E. Holliday, and R. Glaser (1983), Virology 129, 199-206) concluded that these cells were transformed by virus that arose as the result of marker rescue of a transformation-incompetent deletion mutant of EBV. We compared viral DNA sequences in prototype EBV strains with data presented in the Virology paper. Our findings are not consistent with the data of Stoerker et al. and indicate that the cell lines supplied to us did not arise by "marker rescue" but appear to contain the Jijoye viral genome.

摘要

我们分析了两种细胞系HI - 26 - 36和HI - HFX中的爱泼斯坦-巴尔病毒（Epstein - Barr virus，EBV）DNA序列。斯托尔克等人（J. Stoerker、J.E. Holliday和R. Glaser（1983年），《病毒学》129卷，第199 - 206页）得出结论，这些细胞是由病毒转化而来的，该病毒是EBV转化无能力缺失突变体的标记拯救结果。我们将原型EBV毒株中的病毒DNA序列与《病毒学》论文中呈现的数据进行了比较。我们的发现与斯托尔克等人的数据不一致，表明提供给我们的细胞系并非通过“标记拯救”产生，而是似乎包含吉乔伊（Jijoye）病毒基因组。