乳腺癌治疗中放射治疗的个体化实施
Personalizing Radiation Treatment Delivery in the Management of Breast Cancer.
作者信息
Ahmed Kamran A, Grass G Daniel, Orman Amber G, Liveringhouse Casey, Montejo Michael E, Soliman Hatem H, Han Heather S, Czerniecki Brian J, Torres-Roca Javier F, Diaz Roberto
机构信息
Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
University of South Florida College of Medicine, Tampa, FL 33612, USA.
出版信息
Int J Breast Cancer. 2018 Jun 10;2018:6729802. doi: 10.1155/2018/6729802. eCollection 2018.
Long-term data establishes the efficacy of radiotherapy in the adjuvant management of breast cancer. New dose and fractionation schemas have evolved and are available, each with unique risks and rewards. Current efforts are ongoing to tailor radiotherapy to the unique biology of breast cancer. In this review, we discuss our efforts to personalize radiotherapy dosing using genomic data and the implications for future clinical trials. We also explore immune mechanisms that may contribute to a tumor's unique radiation sensitivity or resistance.
长期数据证实了放疗在乳腺癌辅助治疗中的疗效。新的剂量和分割方案不断发展并已可供使用，每种方案都有其独特的风险和益处。目前正在努力使放疗适应乳腺癌的独特生物学特性。在本综述中，我们讨论了利用基因组数据实现放疗剂量个体化的努力以及对未来临床试验的影响。我们还探讨了可能导致肿瘤具有独特放射敏感性或抗性的免疫机制。
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