• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis.

作者信息

Barra Fabio, Ferro Desideri Lorenzo, Ferrero Simone

机构信息

Academic Unit of Obstetrics and Gynecology, Ospedale Policlinico San Martino, Genoa, Italy.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy.

出版信息

Br J Pharmacol. 2018 Sep;175(17):3626-3627. doi: 10.1111/bph.14391. Epub 2018 Jul 8.

DOI:10.1111/bph.14391
PMID:29984446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6086976/
Abstract
摘要

相似文献

1
Inhibition of PI3K/AKT/mTOR pathway for the treatment of endometriosis.抑制PI3K/AKT/mTOR通路用于治疗子宫内膜异位症。
Br J Pharmacol. 2018 Sep;175(17):3626-3627. doi: 10.1111/bph.14391. Epub 2018 Jul 8.
2
Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model.抑制 PI3K/Akt/mTOR 信号通路对大鼠模型坐骨子宫内膜异位症疼痛的影响。
Can J Physiol Pharmacol. 2019 Oct;97(10):963-970. doi: 10.1139/cjpp-2019-0156. Epub 2019 Aug 28.
3
Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.抑制自噬增强了 PI3K/AKT/mTOR 抑制剂 NVP-BEZ235 在肾癌细胞中诱导的细胞凋亡。
Cell Biochem Funct. 2013 Jul;31(5):427-33. doi: 10.1002/cbf.2917. Epub 2012 Oct 22.
4
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR Inhibitor NVP-BEZ235 in Breast Cancer Cells.自噬抑制增强PI3K/mTOR抑制剂NVP-BEZ235诱导的乳腺癌细胞增殖抑制和凋亡
Clin Lab. 2015;61(8):1043-51. doi: 10.7754/clin.lab.2015.150144.
5
Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt's lymphoma.槲皮素同时降低c-Myc表达和PI3K/AKT/mTOR信号传导，对伯基特淋巴瘤产生强烈的细胞毒性作用。
Int J Biochem Cell Biol. 2016 Oct;79:393-400. doi: 10.1016/j.biocel.2016.09.006. Epub 2016 Sep 9.
6
Autophagy protects against PI3K/Akt/mTOR-mediated apoptosis of spinal cord neurons after mechanical injury.自噬可保护脊髓神经元免受机械损伤后PI3K/Akt/mTOR介导的细胞凋亡。
Neurosci Lett. 2017 Aug 24;656:158-164. doi: 10.1016/j.neulet.2017.07.036. Epub 2017 Jul 21.
7
Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.蟾蜍灵，一种来自蟾蜍毒液的天然蟾毒内酯，通过抑制 PI3K/Akt/mTOR 通路诱导人肝癌细胞凋亡和自噬。
Carcinogenesis. 2013 Jun;34(6):1331-42. doi: 10.1093/carcin/bgt060. Epub 2013 Feb 7.
8
Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis.抑制 PI3K/AKT/mTOR 信号通路可促进骨关节炎大鼠关节软骨细胞自噬并减轻炎症反应。
Biomed Pharmacother. 2017 May;89:1252-1261. doi: 10.1016/j.biopha.2017.01.130. Epub 2017 Mar 17.
9
Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway.红景天苷通过 PI3K/Akt/mTOR 通路诱导人胃癌 AGS 细胞凋亡和保护性自噬。
Biomed Pharmacother. 2020 Feb;122:109726. doi: 10.1016/j.biopha.2019.109726. Epub 2019 Dec 30.
10
Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway.Notch信号通路的抑制通过自噬激活和PTEN-PI3K/AKT/mTOR途径促进间充质干细胞的成脂分化。
Cell Physiol Biochem. 2015;36(5):1991-2002. doi: 10.1159/000430167. Epub 2015 Jul 17.

引用本文的文献

1
Warburg-like Metabolic Reprogramming in Endometriosis: From Molecular Mechanisms to Therapeutic Approaches.子宫内膜异位症中类似瓦伯格效应的代谢重编程：从分子机制到治疗方法
Pharmaceuticals (Basel). 2025 May 28;18(6):813. doi: 10.3390/ph18060813.
2
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease.活化的小胶质细胞产生的肿瘤坏死因子的自分泌正反馈，据推测在慢性神经疾病中具有广泛的相关性。
Pharmacol Res Perspect. 2023 Oct;11(5):e01136. doi: 10.1002/prp2.1136.
3
What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis?经血来源间充质干细胞的转录组和蛋白质组能告诉我们关于子宫内膜异位症的什么信息？
Int J Mol Sci. 2022 Sep 29;23(19):11515. doi: 10.3390/ijms231911515.
4
Effect and mechanisms of kaempferol against endometriosis based on network pharmacology and in vitro experiments.基于网络药理学和体外实验研究山奈酚治疗子宫内膜异位症的作用及机制。
BMC Complement Med Ther. 2022 Oct 2;22(1):254. doi: 10.1186/s12906-022-03729-4.
5
Evaluation of NF1 and RASA1 gene expression in endometriosis.子宫内膜异位症中NF1和RASA1基因表达的评估。
Eur J Obstet Gynecol Reprod Biol X. 2022 May 4;15:100152. doi: 10.1016/j.eurox.2022.100152. eCollection 2022 Aug.
6
Genomic Evidence Supports the Recognition of Endometriosis as an Inflammatory Systemic Disease and Reveals Disease-Specific Therapeutic Potentials of Targeting Neutrophil Degranulation.基因组证据支持将子宫内膜异位症视为一种炎症性系统性疾病，并揭示了针对中性粒细胞脱颗粒的靶向治疗的疾病特异性治疗潜力。
Front Immunol. 2022 Mar 23;13:758440. doi: 10.3389/fimmu.2022.758440. eCollection 2022.
7
Using network pharmacology and molecular docking to explore the underlying anti-inflammatory mechanism of Wuyao-Danshen to treat endometriosis.运用网络药理学和分子对接技术探讨乌药-丹参治疗子宫内膜异位症的潜在抗炎机制。
Ann Transl Med. 2022 Feb;10(4):198. doi: 10.21037/atm-22-419.
8
MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.微小 RNA miR-106a-5p 靶向叉头框转录因子 FOXC1 抑制异位子宫内膜基质细胞的增殖、迁移和侵袭，通过 PI3K/Akt/mTOR 信号通路。
Bioengineered. 2021 Dec;12(1):2203-2213. doi: 10.1080/21655979.2021.1933679.
9
MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2.微小 RNA-342 通过调节膜联蛋白 A2 促进子宫内膜基质细胞的恶性表型。
Anal Cell Pathol (Amst). 2021 May 15;2021:1328682. doi: 10.1155/2021/1328682. eCollection 2021.
10
Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network.构建并拓扑分析子宫内膜异位症相关的外泌体 circRNA-miRNA-mRNA 调控网络。
Aging (Albany NY). 2021 Apr 26;13(9):12607-12630. doi: 10.18632/aging.202937.

本文引用的文献

1
Targeting the PI3K pathway in cancer: are we making headway?针对癌症中的 PI3K 通路：我们是否取得进展？
Nat Rev Clin Oncol. 2018 May;15(5):273-291. doi: 10.1038/nrclinonc.2018.28. Epub 2018 Mar 6.
2
In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis.MK2206 与氯喹联合治疗对子宫内膜异位症的体内外作用：自噬可能是子宫内膜异位症复发所必需的。
Br J Pharmacol. 2018 May;175(10):1637-1653. doi: 10.1111/bph.14170. Epub 2018 Apr 16.
3
Everolimus as an mTOR Inhibitor Suppresses Endometriotic Implants: an Experimental Rat Study.依维莫司作为一种mTOR抑制剂可抑制子宫内膜异位症植入物：一项大鼠实验研究。
Geburtshilfe Frauenheilkd. 2017 Jan;77(1):66-72. doi: 10.1055/s-0042-115566.
4
Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.羟氯喹和氯喹在治疗系统性红斑狼疮、类风湿关节炎及相关疾病中的治疗和药理学特性。
Inflammopharmacology. 2015 Oct;23(5):231-69. doi: 10.1007/s10787-015-0239-y. Epub 2015 Aug 6.
5
Influence of AKT on progesterone action in endometrial diseases.AKT对子宫内膜疾病中孕酮作用的影响。
Biol Reprod. 2014 Sep;91(3):63. doi: 10.1095/biolreprod.114.119255. Epub 2014 Aug 6.