低度炎症即使在低密度脂蛋白胆固醇（LDL-C）水平非常低时也会改变心血管风险：我们是否应追求双重目标概念？ - Suppr

Low-Grade Inflammation Modifies Cardiovascular Risk Even at Very Low LDL-C Levels: Are We Aiming for a Dual Target Concept?

作者信息

Koenig Wolfgang

机构信息

Deutsches Herzzentrum München, Technische Universität München, Germany. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany.

出版信息

Circulation. 2018 Jul 10;138(2):150-153. doi: 10.1161/CIRCULATIONAHA.118.035107.

DOI:10.1161/CIRCULATIONAHA.118.035107

PMID:29986958

Abstract

摘要

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Low-Grade Inflammation Modifies Cardiovascular Risk Even at Very Low LDL-C Levels: Are We Aiming for a Dual Target Concept?低度炎症即使在低密度脂蛋白胆固醇（LDL-C）水平非常低时也会改变心血管风险：我们是否应追求双重目标概念？

Circulation. 2018 Jul 10;138(2):150-153. doi: 10.1161/CIRCULATIONAHA.118.035107.

Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation.升高的残余胆固醇既引起低度炎症又引起缺血性心脏病，而升高的低密度脂蛋白胆固醇引起缺血性心脏病而无炎症。

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Association of LDL cholesterol and inflammation with cardiovascular events and mortality in hemodialysis patients with type 2 diabetes mellitus.2型糖尿病血液透析患者中低密度脂蛋白胆固醇和炎症与心血管事件及死亡率的关联

Am J Kidney Dis. 2009 Nov;54(5):902-11. doi: 10.1053/j.ajkd.2009.06.029. Epub 2009 Sep 25.

Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events.C反应蛋白与低密度脂蛋白胆固醇水平在首次心血管事件预测中的比较。

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Predictive value of remnant lipoprotein for cardiovascular events in patients with coronary artery disease after achievement of LDL-cholesterol goals.载脂蛋白残粒对 LDL-胆固醇目标达标后冠心病患者心血管事件的预测价值。

Atherosclerosis. 2011 Sep;218(1):163-7. doi: 10.1016/j.atherosclerosis.2011.04.040. Epub 2011 May 6.

Remnant cholesterol as a cause of ischemic heart disease: evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment.残余胆固醇导致缺血性心脏病：证据、定义、检测、致动脉粥样硬化性、高危患者，以及当前和未来的治疗。

Pharmacol Ther. 2014 Mar;141(3):358-67. doi: 10.1016/j.pharmthera.2013.11.008. Epub 2013 Nov 26.

Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT.依折麦布联合辛伐他汀使双重低密度脂蛋白胆固醇和高敏 C 反应蛋白目标达标更频繁，并改善 IMPROVE-IT 结局。

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Metabolic syndrome is strongly associated with chronic subclinical inflammation in patients achieving optimal low-density lipoprotein-cholesterol levels in secondary prevention of cardiovascular disease.在心血管疾病二级预防中达到最佳低密度脂蛋白胆固醇水平的患者中，代谢综合征与慢性亚临床炎症密切相关。

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Altering the pathophysiology of atherosclerosis: the multidimensional role of statins.改变动脉粥样硬化的病理生理学：他汀类药物的多维作用。

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[Diabetic dyslipidaemia and the atherosclerosis].[糖尿病血脂异常与动脉粥样硬化]

Orv Hetil. 2016 May 8;157(19):746-52. doi: 10.1556/650.2016.30441.

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Low-Grade Inflammation Modifies Cardiovascular Risk Even at Very Low LDL-C Levels: Are We Aiming for a Dual Target Concept?

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