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远志及其成分知母皂苷AIII可诱导胰腺癌细胞的细胞周期停滞和凋亡。

Bunge and its constituent timosaponin-AIII induce cell cycle arrest and apoptosis in pancreatic cancer cells.

作者信息

MarElia Catherine B, Sharp Arielle E, Shemwell Tiffany A, Clare Zhang Y, Burkhardt Brant R

机构信息

Department of Cell Biology, Microbiology and Molecular Biology University of South Florida Tampa FL USA.

Practice of Oriental Medicine Tucson AZ USA.

出版信息

FEBS Open Bio. 2018 Jun 11;8(7):1155-1166. doi: 10.1002/2211-5463.12457. eCollection 2018 Jul.

DOI:10.1002/2211-5463.12457
PMID:29988574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6026701/
Abstract

Pancreatic cancer is one of the most recalcitrant and lethal of all cancers. We examined the effects of (AA) and timosaponin-AIII (TAIII), a steroidal saponin present in AA, on pancreatic cancer cell proliferation and aimed to elucidate their potential apoptotic mechanisms of action. Viability assays and cell cycle analysis revealed that both AA and TAIII significantly inhibited pancreatic cancer cell proliferation and cell cycle progression compared to treatment with gemcitabine, the standard chemotherapeutic agent for advanced pancreatic cancer. We identified a dose-dependent increase in caspase-dependent apoptosis and activation of pro-apoptotic PI3K/Akt pathway proteins, with a subsequent downregulation of pro-survival PI3K/Akt pathway proteins, in pancreatic cancer cells treated with AA or TAIII over those treated with gemcitabine.

摘要

胰腺癌是所有癌症中最难治疗且最致命的癌症之一。我们研究了龙葵提取物（AA）和AA中含有的甾体皂苷知母皂苷AIII（TAIII）对胰腺癌细胞增殖的影响，并旨在阐明它们潜在的凋亡作用机制。活力测定和细胞周期分析表明，与晚期胰腺癌的标准化疗药物吉西他滨相比，AA和TAIII均显著抑制胰腺癌细胞增殖和细胞周期进程。我们发现，与用吉西他滨处理的细胞相比，用AA或TAIII处理的胰腺癌细胞中，半胱天冬酶依赖性凋亡呈剂量依赖性增加，促凋亡PI3K/Akt信号通路蛋白被激活，随后促生存PI3K/Akt信号通路蛋白下调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/b84c15b9f39c/FEB4-8-1155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/9cf757353a4c/FEB4-8-1155-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/02b7e41824d4/FEB4-8-1155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/2c75e7dd2c34/FEB4-8-1155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/b84c15b9f39c/FEB4-8-1155-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/9cf757353a4c/FEB4-8-1155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/e5c696c13102/FEB4-8-1155-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/02b7e41824d4/FEB4-8-1155-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/2c75e7dd2c34/FEB4-8-1155-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b2/6026701/b84c15b9f39c/FEB4-8-1155-g007.jpg

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