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颗粒物对过敏性呼吸道疾病的影响。

Effects of particulate matter on allergic respiratory diseases.

作者信息

Wu Jin-Zhun, Ge Dan-Dan, Zhou Lin-Fu, Hou Ling-Yun, Zhou Ying, Li Qi-Yuan

机构信息

Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China.

Children's Medicine Institute of Medical College, Xiamen University, Xiamen, Fujian 361102, China.

出版信息

Chronic Dis Transl Med. 2018 Jun 8;4(2):95-102. doi: 10.1016/j.cdtm.2018.04.001. eCollection 2018 Jun.

Abstract

The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with allergic respiratory diseases, an increasing number of follow-up empirical studies are being conducted to investigate the mechanisms underlying the toxic effects of PM on asthma and allergic rhinitis. In this review, we have briefly introduced the characteristics of PM and discussed its effects on public health. Subsequently, we have focused on recent studies to elucidate the association between PM and the allergic symptoms of human respiratory diseases. Specifically, we have discussed the mechanism of action of PM in allergic respiratory diseases according to different subtypes: coarse PM (PM), fine PM (PM), and ultrafine PM.

摘要

空气中颗粒物(PM)对健康的影响长期以来一直是临床医生、生物学家和公众关注的问题。随着许多流行病学研究证实PM与过敏性呼吸道疾病之间的关联,越来越多的后续实证研究正在开展,以探究PM对哮喘和过敏性鼻炎产生毒性作用的潜在机制。在本综述中,我们简要介绍了PM的特征,并讨论了其对公众健康的影响。随后,我们重点关注了近期研究,以阐明PM与人类呼吸道疾病过敏症状之间的关联。具体而言,我们根据不同亚型,即粗颗粒物(PM)、细颗粒物(PM)和超细颗粒物,讨论了PM在过敏性呼吸道疾病中的作用机制。

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