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小鼠中7S RNA序列与κ轻链基因的连锁关系。

Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.

作者信息

Taylor B A, Rowe L, Gibson D M, Riblet R, Yetter R, Gottlieb P D

出版信息

Immunogenetics. 1985;22(5):471-81. doi: 10.1007/BF00418092.

DOI:10.1007/BF00418092
PMID:2998983
Abstract

A mouse 7S RNA cDNA plasmid clone was employed to identify and map DNA restriction fragment variants using recombinant inbred (RI) and congenic mouse strains. More than a dozen such restriction variants were identified and mapped to different regions of the mouse genome. One such variant, designated Rn7s-6, showed close linkage to the Ly-2,3-Igk-V (T lymphocyte antigens 2 and 3, kappa immunoglobulin variable region) cluster of markers on chromosome 6. No recombinants were detected among three of these markers in 59 RI strains. On the basis of these data, the Rn7s-6 sequence may be placed within 1.3 centimorgans of Ly-3 and one of the Igk-V-region markers, Igk-Ef1. Two mouse stocks with previously identified crossovers within the Ly-2,3-Igk-V region were used to sublocalize Rn7s-6. The results are consistent with the gene order (Ly-2, Ly-3)-(Rn7s-6, Igk-Ef1)-Igk-Ef2. Several mouse plasmacytomas, known to have various parts of the kappa chain complex deleted, retain the Rn7s-6 sequence. The Rn7s-6 variant is a plus/minus variant; no sequence allelic to Rn7s-6 is found in inbred strains that share the Ly-3a-Igk-Ef1a haplotype.

摘要

利用重组近交（RI）和同源近交系小鼠品系，采用小鼠7S RNA cDNA质粒克隆来鉴定和定位DNA限制性片段变体。已鉴定出十多种此类限制性变体，并将其定位到小鼠基因组的不同区域。其中一个变体，命名为Rn7s - 6，显示出与6号染色体上的Ly - 2,3 - Igk - V（T淋巴细胞抗原2和3、κ免疫球蛋白可变区）标记簇紧密连锁。在59个RI品系的这三个标记中未检测到重组体。基于这些数据，Rn7s - 6序列可能位于Ly - 3和其中一个Igk - V区域标记Igk - Ef1的1.3厘摩范围内。使用两个在Ly - 2,3 - Igk - V区域内先前已鉴定出交叉的小鼠品系来进一步定位Rn7s - 6。结果与基因顺序（Ly - 2, Ly - 3）-（Rn7s - 6, Igk - Ef1）- Igk - Ef2一致。已知有几种小鼠浆细胞瘤缺失了κ链复合体的不同部分，但仍保留Rn7s - 6序列。Rn7s - 6变体是一个正负变体；在共享Ly - 3a - Igk - Ef1a单倍型的近交系中未发现与Rn7s - 6等位的序列。

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1
Linkage of a 7S RNA sequence and kappa light chain genes in the mouse.小鼠中7S RNA序列与κ轻链基因的连锁关系。
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2
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引用本文的文献

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Yeast artificial chromosome contigs reveal that distal variable-region genes reside at least 3 megabases from the joining regions in the murine immunoglobulin kappa locus.酵母人工染色体重叠群显示，在小鼠免疫球蛋白κ基因座中，远端可变区基因位于距连接区至少3兆碱基处。
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12421-5. doi: 10.1073/pnas.92.26.12421.
2
The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6.小鼠6号染色体上免疫球蛋白可变κ链基因的组织
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3
The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers.

本文引用的文献

1
Construction and properties of new Lyt-congenic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies.新型 Lyt 同基因株系的构建与特性，以及抗 Lyt-2.2 和抗 Lyt-3.1 单克隆抗体。
Immunogenetics. 1980;10(6):545-55. doi: 10.1007/BF01572589.
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Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.对源自“自身免疫性”（NZB）和“高白血病”（C58）品系的重组近交系的分析：独立的多基因系统控制B细胞活性亢进、逆转录病毒表达和自身免疫。
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Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cells.
小鼠6号染色体上的内源性逆转录病毒Mtv-8定位在几个κ轻链标记附近。
Immunogenetics. 1987;25(4):222-7. doi: 10.1007/BF00404691.
4
Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.通过Southern杂交和核苷酸序列分析证明的小鼠免疫球蛋白Jκ基因座（Igk-J）的遗传多态性。
Immunogenetics. 1986;24(3):150-7. doi: 10.1007/BF00364742.
5
Structural and evolutionary comparisons of four alleles of the mouse immunoglobulin kappa chain gene, Igk-VSer.小鼠免疫球蛋白κ链基因Igk-VSer的四个等位基因的结构与进化比较
Immunogenetics. 1989;29(4):249-57. doi: 10.1007/BF00717909.
6
The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6.小鼠免疫球蛋白κ轻链基因位于6号染色体的早期和晚期复制区域。
Mol Cell Biol. 1990 Aug;10(8):4314-23. doi: 10.1128/mcb.10.8.4314-4323.1990.
7
Mouse map of paralogous genes.同源基因的小鼠图谱。
Mamm Genome. 1991;1 Spec No:S433-60. doi: 10.1007/BF00656503.
8
Mouse chromosome 6.小鼠6号染色体。
Mamm Genome. 1992;3 Spec No:S81-103. doi: 10.1007/BF00648424.
9
Fine-structure mapping of the complex locus Odc-rs5 relative to Igk and distal loci.复杂基因座Odc-rs5相对于Igk及远端基因座的精细结构图谱
Mamm Genome. 1992;3(12):689-99. doi: 10.1007/BF00444364.
10
Mapping of the mouse ornithine decarboxylase-related sequence family.小鼠鸟氨酸脱羧酶相关序列家族的图谱绘制。
Mamm Genome. 1992;2(4):215-32. doi: 10.1007/BF00355431.
小鼠细胞中丰富的细胞质7S RNA的克隆与特性分析
Nucleic Acids Res. 1982 Jul 24;10(14):4259-77. doi: 10.1093/nar/10.14.4259.
4
DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.免疫球蛋白κ轻链可变基因片段与连接基因片段之间的DNA经常保留在重排κ基因座的细胞中。
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5
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J Biol Chem. 1982 May 10;257(9):5136-42.
6
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Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments.免疫球蛋白V/J重组伴随着连接位点和可变区片段的缺失。
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9
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10
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Cell. 1980 Aug;21(1):1-12. doi: 10.1016/0092-8674(80)90109-9.