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J Exp Med. 1979 Jun 1;149(6):1477-86. doi: 10.1084/jem.149.6.1477.
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1
Sequence diversity within a subgroup of mouse immunoglobulin kappa chains controlled by the IgK-Ef2 locus.由IgK-Ef2基因座控制的小鼠免疫球蛋白κ链亚组内的序列多样性。
J Exp Med. 1981 Jul 1;154(1):146-55. doi: 10.1084/jem.154.1.146.
2
Unique V kappa group associated with two mouse L chain genetic markers.与两个小鼠轻链遗传标记相关的独特Vκ基因群
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Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.编码κ链Ser亚群轻链的单个基因中的结构差异解释了两种小鼠轻链遗传标记的存在。
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本文引用的文献

1
Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.Ly-C：第三个基因座，它决定了仅在胸腺细胞和淋巴细胞上表达的同种异体抗原。
Transplantation. 1971 Mar;11(3):351-3.
2
Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.重组近交系：有助于寻找组织相容性及其他基因的身份、连锁关系和功能。
Transplantation. 1971 Mar;11(3):325-7. doi: 10.1097/00007890-197103000-00013.
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Hypodactyly, a semidominant lethal mutation in mice.少趾畸形，小鼠中的一种半显性致死突变。
J Hered. 1970 Sep-Oct;61(5):219-20. doi: 10.1093/oxfordjournals.jhered.a108088.
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Variability in the lambda light chain sequences of mouse antibody.小鼠抗体λ轻链序列的变异性
Nature. 1970 Dec 12;228(5276):1045-7. doi: 10.1038/2281045a0.
5
A genetic marker in the variable region of light chains of mouse immunoglobulins.小鼠免疫球蛋白轻链可变区中的一种遗传标记。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9. doi: 10.1073/pnas.67.3.1192.
6
Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse.小鼠中决定分化同种异体抗原的基因座的遗传连锁关系。
Transplantation. 1972 Mar;13(3):239-43. doi: 10.1097/00007890-197203000-00007.
7
Immunoglobulin-producing tumors and myeloma proteins of mice.小鼠产生免疫球蛋白的肿瘤和骨髓瘤蛋白
Physiol Rev. 1972 Jul;52(3):631-719. doi: 10.1152/physrev.1972.52.3.631.
8
Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.小鼠轻链可变区标记与胸腺细胞表面抗原的遗传相关性。
J Exp Med. 1974 Nov 1;140(5):1432-7. doi: 10.1084/jem.140.5.1432.
9
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.Ly - A和Ly - B：小鼠淋巴细胞同种抗原的两个系统。
Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93. doi: 10.1098/rspb.1968.0032.
10
Standardized nomenclature for inbred strains of mice: sixth listing.小鼠近交系标准化命名法：第六版名录
Cancer Res. 1976 Dec;36(12):4333-77.

Ef2：一种在正常小鼠血清免疫球蛋白中表达的新型LY-3连接轻链标志物。

Ef2: a new LY-3-linked light-chain marker expressed in normal mouse serum immunoglobulin.

作者信息

Gibson D M, MacLean S J

出版信息

J Exp Med. 1979 Jun 1;149(6):1477-86. doi: 10.1084/jem.149.6.1477.

DOI:10.1084/jem.149.6.1477
PMID:109570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184900/
Abstract

A new light-chain marker has been detected in normal mouse serum immunoglobulin light chains by gel isoelectric focusing. The marker (Ef2) involves the presence of two major and several minor bands in the normal light-chain IF profiles. Strains expressing the marker IF bands are designated Igk-Ef2a, whereas those lacking the bands are Igk-Ef2b. The majority of inbred strains are Igk-Ef2a. Strains found to be Igk-Ef2b are NZB/BlNJ, BDP/J, C58/J, I/LnJ, CE/J, and P/J. The strain distribution of the alleles differs from the distribution of alleles at the Ly-2 and Ly-3 loci, suggesting the new marker may represent a separate locus. Genetic studies have shown that Igk-Ef2 locus is closely linked to Igk-Ef1 and Hd loci on Chromosome 6, indicating that it is also closely linked to Ly-3. The relative importance of the bands controlled by the Igk-Ef2 locus suggests that the entire normal light-chain pool could be controlled by as few as 100 such loci.

摘要

通过凝胶等电聚焦法在正常小鼠血清免疫球蛋白轻链中检测到一种新的轻链标志物。该标志物（Ef2）在正常轻链免疫荧光图谱中表现为两条主要条带和几条次要条带。表达该标志物免疫荧光条带的品系被指定为Igk-Ef2a，而缺乏这些条带的品系为Igk-Ef2b。大多数近交系是Igk-Ef2a。被发现为Igk-Ef2b的品系有NZB/BlNJ、BDP/J、C58/J、I/LnJ、CE/J和P/J。该等位基因的品系分布与Ly-2和Ly-3位点的等位基因分布不同，这表明新标志物可能代表一个独立的位点。遗传学研究表明，Igk-Ef2位点与6号染色体上的Igk-Ef1和Hd位点紧密连锁，这表明它也与Ly-3紧密连锁。由Igk-Ef2位点控制的条带的相对重要性表明，整个正常轻链库可能仅由多达100个这样的位点控制。