Ef2：一种在正常小鼠血清免疫球蛋白中表达的新型LY-3连接轻链标志物。
Ef2: a new LY-3-linked light-chain marker expressed in normal mouse serum immunoglobulin.
作者信息
Gibson D M, MacLean S J
出版信息
J Exp Med. 1979 Jun 1;149(6):1477-86. doi: 10.1084/jem.149.6.1477.
Abstract
A new light-chain marker has been detected in normal mouse serum immunoglobulin light chains by gel isoelectric focusing. The marker (Ef2) involves the presence of two major and several minor bands in the normal light-chain IF profiles. Strains expressing the marker IF bands are designated Igk-Ef2a, whereas those lacking the bands are Igk-Ef2b. The majority of inbred strains are Igk-Ef2a. Strains found to be Igk-Ef2b are NZB/BlNJ, BDP/J, C58/J, I/LnJ, CE/J, and P/J. The strain distribution of the alleles differs from the distribution of alleles at the Ly-2 and Ly-3 loci, suggesting the new marker may represent a separate locus. Genetic studies have shown that Igk-Ef2 locus is closely linked to Igk-Ef1 and Hd loci on Chromosome 6, indicating that it is also closely linked to Ly-3. The relative importance of the bands controlled by the Igk-Ef2 locus suggests that the entire normal light-chain pool could be controlled by as few as 100 such loci.
摘要
通过凝胶等电聚焦法在正常小鼠血清免疫球蛋白轻链中检测到一种新的轻链标志物。该标志物（Ef2）在正常轻链免疫荧光图谱中表现为两条主要条带和几条次要条带。表达该标志物免疫荧光条带的品系被指定为Igk-Ef2a，而缺乏这些条带的品系为Igk-Ef2b。大多数近交系是Igk-Ef2a。被发现为Igk-Ef2b的品系有NZB/BlNJ、BDP/J、C58/J、I/LnJ、CE/J和P/J。该等位基因的品系分布与Ly-2和Ly-3位点的等位基因分布不同，这表明新标志物可能代表一个独立的位点。遗传学研究表明，Igk-Ef2位点与6号染色体上的Igk-Ef1和Hd位点紧密连锁，这表明它也与Ly-3紧密连锁。由Igk-Ef2位点控制的条带的相对重要性表明，整个正常轻链库可能仅由多达100个这样的位点控制。
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