Pang Xin, Tang Ya-Jie, Ren Xiao-Hua, Chen Qian-Ming, Tang Ya-Ling, Liang Xin-Hua
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Microbiol. 2018 Jun 26;9:1353. doi: 10.3389/fmicb.2018.01353. eCollection 2018.
Microbiota has been widely considered to play a critical role in human carcinogenesis. Recent evidence demonstrated that microbiota, epithelial barrier and inflammation has made up a tightly interdependent triangle during the process of carcinogenesis. Hence, we discussed the triangle relationship of microbiota dysbiosis, epithelial barrier dysfunction and dysregulated immune responses to elucidate the mechanisms by which microbiota induces carcinogenesis, especially highlighting the reciprocal crosstalk between transforming growth factor-β signaling and every side of the tumorigenic triangle. This sophisticated interaction will provide insight into the basic mechanisms of carcinogenesis and may bring new hope to cancer prevention and therapeutic intervention.
微生物群被广泛认为在人类致癌过程中起着关键作用。最近的证据表明，在致癌过程中，微生物群、上皮屏障和炎症构成了一个紧密相互依存的三角关系。因此，我们讨论了微生物群失调、上皮屏障功能障碍和免疫反应失调之间的三角关系，以阐明微生物群诱导致癌的机制，特别强调了转化生长因子-β信号通路与致癌三角各方面之间的相互串扰。这种复杂的相互作用将为深入了解致癌的基本机制提供思路，并可能为癌症预防和治疗干预带来新的希望。
