Department of Radiology, Tongji University Affiliated Yangpu Hospital, No. 450 Tengyue Road, Shanghai, 200090, China.
Department of General Surgery, Tongji University Affiliated Yangpu Hospital, Shanghai, 200090, China.
World J Surg Oncol. 2018 Jul 12;16(1):138. doi: 10.1186/s12957-018-1445-z.
Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values as imaging biomarkers of rectal cancer are currently a hot research spot. The use of ADC values for preoperative judgment of pathological features in rectal cancer has been generally accepted. The image quality evaluation of conventional diffusion is severe deformation, and the measurement of ADC values can easily lead to bias. Readout-segmented echo-planar diffusion-weighted imaging (RESOLVE) provides high signal-to-noise ratio images and significantly reduces distortions caused by magnetosensitive effects. The purpose of this study was to explore the correlations between ADC values of RESOLVE and pathological prognostic factors in rectal adenocarcinoma.
We collected pathological data of 89 patients with pathologically confirmed rectal adenocarcinoma who directly underwent surgical resection without receiving adjuvant therapy. The patients were grouped according to the pathologic type, gross classification, degree of differentiation, TN stage, and immunohistochemical expression of epidermal growth factor receptor (EGFR).
RESOLVE ADC values of rectal cancer were measured at b = 800, and correlations between the RESOLVE ADC values obtained in different groups were analysed. We found that RESOLVE ADC values in the ulcer-type group were significantly higher than those in the eminence-type group.
RESOLVE ADC values in different pathologic types of rectal cancer were significantly different. RESOLVE ADC values in the EGFR-positive group were significantly lower than those in the EGFR-negative group. There was no significant difference in RESOLVE ADC values between different degrees of pathologic differentiation, TN stages, and positive or negative lymph nodes. The quantitative description of RESOLVE ADC values could be used to assess the biological behaviour of rectal adenocarcinoma.
弥散加权成像（DWI）和表观扩散系数（ADC）值作为直肠癌的影像学标志物，目前是研究热点。ADC 值用于术前判断直肠癌的病理特征已得到普遍认可。常规弥散的图像质量评估存在严重变形，ADC 值的测量容易导致偏差。读出分段回波平面弥散加权成像（RESOLVE）提供了高信噪比的图像，显著降低了磁敏感效应引起的失真。本研究旨在探讨 RESOLVE ADC 值与直肠腺癌病理预后因素的相关性。
我们收集了 89 例经病理证实的直肠腺癌患者的病理数据，这些患者直接接受了手术切除，未接受辅助治疗。根据病理类型、大体分类、分化程度、TN 分期和表皮生长因子受体（EGFR）的免疫组织化学表达，对患者进行分组。
对直肠腺癌的 b 值为 800 时进行 RESOLVE ADC 值测量，并对不同组之间的 RESOLVE ADC 值进行相关性分析。我们发现溃疡型组的 RESOLVE ADC 值明显高于隆起型组。
不同病理类型的直肠癌的 RESOLVE ADC 值有显著差异。EGFR 阳性组的 RESOLVE ADC 值明显低于 EGFR 阴性组。不同病理分化程度、TN 分期、淋巴结阳性或阴性之间的 RESOLVE ADC 值无显著差异。RESOLVE ADC 值的定量描述可用于评估直肠腺癌的生物学行为。
