Khan Sikandar H, Kitsis Michelle, Golovyan Dmitriy, Wang Sophia, Chlan Linda L, Boustani Malaz, Khan Babar A
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN.
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
Heart Lung. 2018 Sep-Oct;47(5):489-496. doi: 10.1016/j.hrtlng.2018.05.015. Epub 2018 Jul 9.
Music listening has been shown to reduce anxiety, stress, and patient tolerance of procedures. Music may also have beneficial effects on inflammatory biomarkers in intensive care and post-operative patients, but the quality of evidence is not clear.
We conducted a systematic review to evaluate the effects of music on inflammatory biomarkers in intensive care, and post-operative patients.
A comprehensive search of the literature was performed. After screening 1570 references, full text review of 26 studies was performed. Fourteen studies were selected for inclusion.
Seven studies showed a significant decrease in cortisol levels, but the level of evidence was low. Three studies had low risk of methodological bias, while 11 studies had high risk of bias.
Music intervention may decrease cortisol levels, but other biomarkers remain unchanged. Given the low level of evidence, further research on music effects on inflammatory biomarkers is needed.
已有研究表明，听音乐可减轻焦虑、压力，并提高患者对手术的耐受性。音乐对重症监护患者和术后患者的炎症生物标志物可能也有有益影响，但证据质量尚不清楚。
我们进行了一项系统评价，以评估音乐对重症监护患者和术后患者炎症生物标志物的影响。
对文献进行全面检索。在筛选了1570篇参考文献后，对26项研究进行了全文审查。最终纳入14项研究。
7项研究显示皮质醇水平显著降低，但证据水平较低。3项研究存在方法学偏倚的风险较低，而11项研究存在较高的偏倚风险。
音乐干预可能会降低皮质醇水平，但其他生物标志物保持不变。鉴于证据水平较低，需要进一步研究音乐对炎症生物标志物的影响。
