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成功使用脂肪来源的间充质干细胞矫正波兰综合征所致男性乳房畸形:1例报告

Successful use of adipose-derived mesenchymal stem cells to correct a male breast affected by Poland Syndrome: a case report.

作者信息

Christopoulos Athanasios, Ligoudistianou Christina, Bethanis Panagiotis, Gazouli Maria

机构信息

Plastic Surgery Clinic, Aesthetic Anaplasis, Athens, Greece.

Theracell Advanced Biotechnology Ltd, Athens, Greece.

出版信息

J Surg Case Rep. 2018 Jul 9;2018(7):rjy151. doi: 10.1093/jscr/rjy151. eCollection 2018 Jul.

DOI:10.1093/jscr/rjy151
PMID:30002805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6037112/
Abstract

Poland syndrome is a rare congenital anomaly in which affected persons are born with missing or underdeveloped muscles on one side of the body. In this case study we present the case of a 28-year-old male with absence of all middle phalanges of the right hand and other rare anomalies, who underwent reconstruction with a new method that combines a mixture of adipose-derived mesenchymal stem cells and fat transfer. The patient's restoration of the pectoralis area was aesthetically successful with no complications and remained unchanged even after 3.5 years. The proposed method represents an interesting reconstructive approach for treating Poland's syndrome deformities.

摘要

波兰综合征是一种罕见的先天性异常疾病,患者出生时身体一侧的肌肉缺失或发育不全。在本病例研究中,我们介绍了一名28岁男性患者,其右手所有中节指骨均缺失,并伴有其他罕见异常,该患者接受了一种新的重建方法,即将脂肪源性间充质干细胞与脂肪移植相结合。患者胸肌区域的修复在美学上取得了成功,没有并发症,即使在3.5年后也保持不变。所提出的方法代表了一种治疗波兰综合征畸形的有趣的重建方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/d4958adf1b71/rjy151f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/345bbc119bca/rjy151f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/d07125acacde/rjy151f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/d4958adf1b71/rjy151f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/345bbc119bca/rjy151f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/d07125acacde/rjy151f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a823/6037112/d4958adf1b71/rjy151f03.jpg

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1
Successful use of adipose-derived mesenchymal stem cells to correct a male breast affected by Poland Syndrome: a case report.成功使用脂肪来源的间充质干细胞矫正波兰综合征所致男性乳房畸形:1例报告
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引用本文的文献

1
A narrative review of Poland's syndrome: theories of its genesis, evolution and its diagnosis and treatment.波兰综合征的叙述性综述:其成因、演变、诊断及治疗的理论
Transl Pediatr. 2021 Apr;10(4):1008-1019. doi: 10.21037/tp-20-320.
2
Reinforcing the vascular disruption theory of the genesis of Poland's syndrome: a rare association of diaphragmatic eventration in a preterm infant with severe musculoskeletal defects.强化波兰氏综合征发病的血管破坏理论:一例罕见的早产儿膈肌膨出伴严重骨骼肌肉缺陷。
BMJ Case Rep. 2021 Jan 28;14(1):e238392. doi: 10.1136/bcr-2020-238392.

本文引用的文献

1
Chest wall reconstruction in male poland syndrome.男性波兰综合征的胸壁重建
Eplasty. 2010 Dec 13;10. eCollection 2010.
2
Bipolar Latissimus Dorsi Transfer for Restoration of Pectoralis Major Function in Poland Syndrome.波兰综合征中使用双极背阔肌转移术恢复胸大肌功能
Ann Plast Surg. 2016 Jan;77(1):85-9. doi: 10.1097/SAP.0000000000000293.
3
Surgical treatment of patients with Poland's syndrome--own experience.波兰综合征患者的手术治疗——自身经验
Pol Przegl Chir. 2011 Dec;83(12):662-7. doi: 10.2478/v10035-011-0106-5.
4
Muscle abnormalities of the chest in Poland's syndrome: variations and proposal for a classification.波兰综合征胸部肌肉异常:变异情况及分类建议
Surg Radiol Anat. 2012 Jan;34(1):57-63. doi: 10.1007/s00276-011-0851-5. Epub 2011 Jul 29.
5
Successful use of squeezed-fat grafts to correct a breast affected by Poland syndrome.成功应用挤压脂肪移植矫正波兰综合征乳房。
Aesthetic Plast Surg. 2011 Jun;35(3):418-25. doi: 10.1007/s00266-010-9601-z. Epub 2010 Oct 17.
6
Adipose-derived stem cells: isolation, expansion and differentiation.脂肪来源干细胞:分离、扩增与分化
Methods. 2008 Jun;45(2):115-20. doi: 10.1016/j.ymeth.2008.03.006. Epub 2008 May 29.
7
Improvement of postnatal neovascularization by human adipose tissue-derived stem cells.人脂肪组织来源干细胞对产后新生血管形成的改善作用。
Circulation. 2004 Jul 20;110(3):349-55. doi: 10.1161/01.CIR.0000135466.16823.D0. Epub 2004 Jul 6.
8
Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells.人脂肪基质细胞分泌血管生成因子和抗凋亡因子。
Circulation. 2004 Mar 16;109(10):1292-8. doi: 10.1161/01.CIR.0000121425.42966.F1. Epub 2004 Mar 1.
9
Complications with homologous fat grafts in breast augmentation surgery.
Aesthetic Plast Surg. 1985;9(2):87-9. doi: 10.1007/BF01570334.