人白细胞干扰素与壬苯醇醚9对2型单纯疱疹病毒的协同作用。
Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.
作者信息
Rapp F, Wrzos H
出版信息
Antimicrob Agents Chemother. 1985 Sep;28(3):449-51. doi: 10.1128/AAC.28.3.449.
Abstract
The nonionic surfactant nonoxynol 9 (NP9), in combination with human alpha interferon, synergistically reduced the titer of herpes simplex virus type 2 (HSV-2) in vitro. The degree of synergy was highest at an interferon concentration of 10(3) IU/ml and an NP9 dilution of 1:1,500. We postulate that NP9 inactivates extracellular HSV-2, whereas interferon inhibits HSV-2 replication at the intracellular level.
摘要
非离子表面活性剂壬苯醇醚9（NP9）与人类α干扰素联合使用时，在体外能协同降低2型单纯疱疹病毒（HSV-2）的滴度。在干扰素浓度为10³ IU/ml且NP9稀释度为1:1500时，协同程度最高。我们推测，NP9可使细胞外的HSV-2失活，而干扰素在细胞内水平抑制HSV-2复制。
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