Leventis Minas, Agrogiannis George, Fairbairn Peter, Vasiliadis Orestis, Papavasileiou Danai, Theodoropoulou Evangelia, Horowitz Robert, Kalyvas Demos
Laboratory of Experimental Surgery and Surgical Research N. S. Christeas, Medical School, University of Athens, 75 M. Assias Street, 115 27 Athens, Greece.
Department of Pathology, Medical School, University of Athens, 75 M. Assias Street, 115 27 Athens, Greece.
Dent J (Basel). 2018 Jul 2;6(3):27. doi: 10.3390/dj6030027.
The purpose of this study was to investigate the effectiveness of a resorbable alloplastic in situ hardening bone grafting material for alveolar ridge preservation in a swine model. Seven Landrace pigs were used. In each animal, the maxillary left and right deciduous second molars were extracted, and extraction sites were either grafted with a resorbable alloplastic in situ hardening bone substitute, composed of beta-tricalcium phosphate (-TCP) granules coated with poly(lactic-co-glycolic) acid (PLGA), or left unfilled to heal spontaneously. Animals were euthanized after 12 weeks, and the bone tissue was analyzed histologically and histomorphometrically. Linear changes of ridge width were also clinically measured and analyzed. Pronounced bone regeneration was found in both experimental and control sites, with no statistically significant differences. At the experimental sites, most of the alloplastic grafting material was resorbed and remnants of the graft particles were severely decreased in size. Moreover, experimental sites showed, in a statistically nonsignificant way, less mean horizontal dimensional reduction of the alveolar ridge (7.69%) compared to the control sites (8.86%). In conclusion, the -TCP/PLGA biomaterial performed well as a biocompatible resorbable in situ hardening bone substitute when placed in intact extraction sockets in this animal model.
本研究的目的是在猪模型中研究一种可吸收的异质原位硬化骨移植材料用于牙槽嵴保存的有效性。使用了7头长白猪。在每只动物中，拔除上颌左右乳第二磨牙，拔牙位点要么用一种可吸收的异质原位硬化骨替代物进行移植，该替代物由涂有聚乳酸-乙醇酸共聚物（PLGA）的β-磷酸三钙（β-TCP）颗粒组成，要么不进行填充任其自发愈合。12周后对动物实施安乐死，并对骨组织进行组织学和组织形态计量学分析。还对牙槽嵴宽度的线性变化进行了临床测量和分析。在实验组和对照组位点均发现明显的骨再生，且无统计学显著差异。在实验组位点，大部分异质移植材料被吸收，移植颗粒的残余物尺寸显著减小。此外，与对照组位点（8.86%）相比，实验组位点牙槽嵴的平均水平尺寸减小较少（7.69%），但差异无统计学意义。总之，在该动物模型中，当将β-TCP/PLGA生物材料置于完整的拔牙窝时，其作为一种生物相容性良好的可吸收原位硬化骨替代物表现良好。
