Department of Virology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; University of Rostock, Rostock, Germany.
National Institute for Public Health of Kosova, Prishtina, Kosovo.
Infect Genet Evol. 2018 Nov;65:6-11. doi: 10.1016/j.meegid.2018.07.010. Epub 2018 Jul 11.
Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a tick-borne virus which causes severe disease in humans with fatality cases up to 30%. We investigated the genetic and evolutionary characteristics of CCHFV in Kosovo, in particular in humans and found that different virus variants of genotype V circulate, with Turkey as a possible origin for the progenitor of southern European CCHF outbreaks. Phylogenetic analyses also revealed a single introduction event and in situ evolution of CCHFV in this country. The viral metagenomics revealed a more abundant virome in the fatal CCHF cases and the presence of a novel tick-borne segmented RNA virus belonging to the recently discovered Jingmenvirus group which raises questions about the potential pathogenic effect of this novel virus on human and animal health.
克里米亚-刚果出血热正尼多病毒（CCHFV）是一种蜱媒病毒，可引起人类严重疾病，病死率高达 30%。我们调查了科索沃的 CCHFV 的遗传和进化特征，特别是在人类中，发现不同基因型 V 的病毒变异株在传播，土耳其可能是南欧 CCHF 暴发的祖先病毒的来源。系统进化分析还显示，CCHFV 在该国发生了单一的传入事件和原地进化。病毒宏基因组学显示，致死性 CCHF 病例中的病毒组更为丰富，并且存在一种新型蜱传分段 RNA 病毒，属于最近发现的荆门病毒群，这引发了关于这种新型病毒对人类和动物健康潜在致病作用的问题。
