Emerg Infect Dis. 2018 Dec;24(12):2202-2209. doi: 10.3201/eid2412.180175.
During 2013-2014, we collected 1,926 serum samples from humans and 4,583 ticks (Hyalomma asiaticum or Dermacentor nuttalli) in select regions of Mongolia to determine the risk for Crimean-Congo hemorrhagic fever virus (CCHFV) infection among humans in this country. Testing of human serum samples by ELISA demonstrated an overall CCHFV antibody prevalence of 1.4%; Bayankhongor Province had the highest prevalence, 2.63%. We pooled and analyzed tick specimens by real-time reverse transcription PCR; 1 CCHFV-positive H. asiaticum tick pool from Ömnögovi was identified. In phylogenetic analyses, the virus's partial small segment clustered with CCHFV isolates from Central Asia, and the complete medium segment grouped with CCHFV isolates from Africa, Asia, and the Middle East. This study confirms CCHFV endemicity in Mongolia and provides information on risk for CCHFV infection. Further research is needed to better define the risk for CCHFV disease to improve risk mitigation, diagnostics, and surveillance.
在 2013-2014 年期间，我们在蒙古国选定地区收集了 1926 份人类血清样本和 4583 份蜱虫（亚洲璃眼蜱或全沟硬蜱），以确定该国人类感染克里米亚-刚果出血热病毒（CCHFV）的风险。通过 ELISA 检测人类血清样本显示，CCHFV 抗体总流行率为 1.4%；巴彦洪戈尔省的流行率最高，为 2.63%。我们通过实时逆转录 PCR 对蜱虫标本进行了汇集和分析；从鄂尔浑省鉴定出一个 CCHFV 阳性的亚洲璃眼蜱虫群。在系统发育分析中，该病毒的部分小片段与从中亚分离的 CCHFV 分离株聚类，完整的中片段与来自非洲、亚洲和中东的 CCHFV 分离株聚类。本研究证实了蒙古的 CCHFV 地方性流行，并提供了关于 CCHFV 感染风险的信息。需要进一步研究以更好地确定 CCHFV 疾病的风险，以改善风险缓解、诊断和监测。
