Children's National Medical Center, Washington, District of Columbia.
Division of Critical Care Medicine, Department of Pediatrics, School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia.
Pediatrics. 2018 Aug;142(2). doi: 10.1542/peds.2017-3360. Epub 2018 Jul 13.
: media-1vid110.1542/5789657761001PEDS-VA_2017-3360 BACKGROUND: Patient safety concerns over the past 2 decades have prompted widespread efforts to reduce adverse events (AEs). It is unclear whether these efforts have resulted in reductions in hospital-wide AE rates. We used a validated safety surveillance tool, the Global Assessment of Pediatric Patient Safety, to measure temporal trends (2007-2012) in AE rates among hospitalized children.
We conducted a retrospective surveillance study of randomly selected pediatric inpatient records from 16 teaching and nonteaching hospitals. We constructed Poisson regression models with hospital random intercepts, controlling for patient age, sex, insurance, and chronic conditions, to estimate changes in AE rates over time.
Examining 3790 records, reviewers identified 414 AEs (19.1 AEs per 1000 patient days; 95% confidence interval [CI] 17.2-20.9) and 210 preventable AEs (9.5 AEs per 1000 patient days; 95% CI 8.2-10.8). On average, teaching hospitals had higher AE rates than nonteaching hospitals (26.2 [95% CI 23.7-29.0] vs 5.1 [95% CI 3.7-7.1] AEs per 1000 patient days, < .001). Chronically ill children had higher AE rates than patients without chronic conditions (33.9 [95% CI 24.5-47.0] vs 14.0 [95% CI 11.8-16.5] AEs per 1000 patient days, < .001). Multivariate analyses revealed no significant changes in AE rates over time. When stratified by hospital type, neither teaching nor nonteaching hospitals experienced significant temporal AE rate variations.
AE rates in pediatric inpatients are high and did not improve from 2007 to 2012. Pediatric AE rates were substantially higher in teaching hospitals as well as in patients with more chronic conditions.
在过去的 20 年中,人们对患者安全问题的关注促使广泛努力减少不良事件(AE)。目前尚不清楚这些努力是否导致医院范围内 AE 发生率的降低。我们使用经过验证的安全监测工具——儿科患者安全全球评估,来衡量住院儿童 AE 发生率的时间趋势(2007-2012 年)。
我们对 16 所教学和非教学医院的随机选择的儿科住院病历进行了回顾性监测研究。我们构建了带有医院随机截距的泊松回归模型,控制患者年龄、性别、保险和慢性疾病,以估计随时间的 AE 发生率变化。
在审查了 3790 份记录后,审查员确定了 414 起 AE(每 1000 个患者日发生 19.1 起 AE;95%置信区间[CI] 17.2-20.9)和 210 起可预防的 AE(每 1000 个患者日发生 9.5 起 AE;95%CI 8.2-10.8)。平均而言,教学医院的 AE 发生率高于非教学医院(26.2[95%CI 23.7-29.0]比每 1000 个患者日 5.1[95%CI 3.7-7.1]起 AE, <.001)。患有慢性疾病的儿童 AE 发生率高于没有慢性疾病的患者(33.9[95%CI 24.5-47.0]比每 1000 个患者日 14.0[95%CI 11.8-16.5]起 AE, <.001)。多变量分析显示,AE 发生率随时间无显著变化。按医院类型分层时,教学医院和非教学医院的 AE 发生率均无明显的时间变化。
儿科住院患者的 AE 发生率较高,并且从 2007 年至 2012 年没有改善。教学医院以及患有更多慢性疾病的患者的儿科 AE 发生率明显更高。