Saito K, Furuta Y, Sano H, Okishio T, Fukuzaki H
Clin Exp Hypertens A. 1985;7(9):1217-32. doi: 10.3109/10641968509073586.
The effects of high sodium intake on erythrocyte 22Na efflux rate constants were studied in 25 patients with essential hypertension and 9 normal subjects. With changes in sodium intake from 100 mEq to 300 mEq/day, both total and ouabain sensitive 22Na efflux rate constants decreased significantly (p less than 0.001) in "salt-sensitive" patients (-0.031 +/- 0.005 and -0.035 +/- 0.006 /hr, respectively), but these responses were variable in "nonsalt-sensitive" patients and in normal subjects. The "salt-sensitive" patients showed a significant increase in their body weight, while intraerythrocyte sodium contents remained unchanged in the both groups. These results suggest that the abnormal change in membrane Na-K-ATPase activity may, at least in part, be involved in the mechanism of sodium susceptibility in patients with essential hypertension.
在25例原发性高血压患者和9名正常受试者中研究了高钠摄入对红细胞22Na流出速率常数的影响。随着钠摄入量从100 mEq/天增加到300 mEq/天，“盐敏感”患者的总22Na流出速率常数和哇巴因敏感的22Na流出速率常数均显著降低（p<0.001）（分别为-0.031±0.005和-0.035±0.006/hr），但这些反应在“非盐敏感”患者和正常受试者中是可变的。“盐敏感”患者体重显著增加，而两组的红细胞内钠含量均保持不变。这些结果表明，膜Na-K-ATP酶活性的异常变化可能至少部分参与原发性高血压患者钠易感性的机制。
