Department of Foods and Nutrition, University of Georgia, 305 Sanford Drive, Athens, GA, 30602, USA.
Department of Statistics, University of Georgia, Athens, GA, 30602, USA.
Mamm Genome. 2018 Oct;29(9-10):619-631. doi: 10.1007/s00335-018-9759-2. Epub 2018 Jul 14.
Glutathione is a ubiquitous antioxidant that protects cells against reactive oxygen species and other chemical stressors. Despite its functional importance, the impact of genetics on the glutathione system has yet to be fully appreciated. Here, we investigated the heritability of glutathione levels and redox status in a disease-relevant condition: advanced age. We assembled a panel of 18-21-month-old mice representing 19 inbred strains and quantified the levels of reduced and oxidized glutathione, and their sums and ratios, in liver, kidney, heart, pancreas, cerebral cortex, and striatum. Heritability values were calculated for each phenotype and the results varied by tissue of origin. Cardiac glutathione phenotypes exhibited the highest heritabilities (G = 0.44-0.67), while striatal glutathione was least heritable (G = 0.11-0.29). Statistical relationships between tissues were evaluated, and the emergence of significant correlations suggested that despite tissue-specific heritabilities, at least some shared regulatory mechanisms may exist. Overall, these data highlight another mechanism by which genetic background determines antioxidant protection and stress resistance.
谷胱甘肽是一种普遍存在的抗氧化剂，可保护细胞免受活性氧和其他化学应激源的侵害。尽管其功能很重要，但遗传对谷胱甘肽系统的影响尚未得到充分认识。在这里，我们研究了与疾病相关的条件下谷胱甘肽水平和氧化还原状态的遗传性：高龄。我们组装了一个由 18-21 个月大的小鼠组成的小组，代表 19 个近交系，并定量测定了肝脏、肾脏、心脏、胰腺、大脑皮层和纹状体中还原型和氧化型谷胱甘肽及其总和和比值。为每个表型计算了遗传力值，结果因组织来源而异。心脏谷胱甘肽表型的遗传力最高（G=0.44-0.67），而纹状体谷胱甘肽的遗传力最低（G=0.11-0.29）。评估了组织之间的统计学关系，出现的显著相关性表明，尽管存在组织特异性遗传力，但至少存在一些共同的调节机制。总的来说，这些数据突出了遗传背景决定抗氧化保护和应激抗性的另一种机制。
