Moutia Mouna, Habti Norddine, Badou Abdallah
Laboratory of Hematology and Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Laboratory of Experimental Medicine and Biotechnology, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Evid Based Complement Alternat Med. 2018 Jun 12;2018:4984659. doi: 10.1155/2018/4984659. eCollection 2018.
L. (garlic), which is a species of the onion family, Alliaceae, is one of the most used plants in traditional medicine worldwide. More than 200 chemicals with diverse properties have been found in garlic extracts. Several garlic compounds were suggested to be efficient in improving various pathologies including certain types of cancer. This paper is an overview of data about garlic biological activities and/or on immune cells, on the development of certain inflammatory diseases, and on different types of carcinomas and sarcomas. Garlic and its compounds were found to have notable antioxidant properties. Garlic therapeutic potential has also been studied in several inflammatory diseases such as allergic-airway inflammation, inflammatory bowel disease, arthritic rheumatism, and atherosclerosis. Furthermore, garlic was found to be able to maintain the immune system homeostasis and to exhibit beneficial effects on immune cells especially through regulation of proliferation and cytokine gene expression. Finally, we will show how major garlic components such as sulfur compounds and polyphenols might be responsible for the garlic biological activities revealed in different situations. If identified, specific compounds present in garlic could potentially be used in therapy.
大蒜属于葱科葱属植物，是全球传统医学中使用最为广泛的植物之一。在大蒜提取物中已发现200多种具有不同特性的化学物质。有几种大蒜化合物被认为对改善包括某些类型癌症在内的各种病症有效。本文概述了有关大蒜生物活性的数据，以及其对免疫细胞、某些炎症性疾病的发展，以及不同类型的癌和肉瘤的影响。研究发现大蒜及其化合物具有显著的抗氧化特性。大蒜的治疗潜力也在几种炎症性疾病中得到了研究，如过敏性气道炎症、炎症性肠病、关节炎性风湿病和动脉粥样硬化。此外，研究发现大蒜能够维持免疫系统的稳态，并对免疫细胞产生有益影响，特别是通过调节细胞增殖和细胞因子基因表达。最后，我们将展示大蒜的主要成分，如硫化合物和多酚，如何可能是不同情况下所揭示的大蒜生物活性的原因。如果能够确定，大蒜中存在的特定化合物有可能用于治疗。
