锰催化的弱配位芳香酮的邻位 C-H 酰胺化反应。
Manganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones.
机构信息
College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , 2999 North Renmin Lu , Shanghai 201620 , China.
出版信息
Org Lett. 2018 Aug 3;20(15):4495-4498. doi: 10.1021/acs.orglett.8b01770. Epub 2018 Jul 16.
PMID:30009611
Abstract
An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ generated reactive Mn intermediate, MnMe(CO). This method offers excellent chemical yields, high regioselectivities, and good functional group tolerance.
摘要
发展了一种高效的锰催化弱配位芳基酮的邻位 C-H 酰胺化反应，使用易得的磺酰基叠氮作为酰胺化试剂。关键步骤是使用原位生成的活性 Mn 中间体 MnMe(CO)进行酮导向的芳基金属化。该方法具有优异的化学收率、高区域选择性和良好的官能团容忍性。
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