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钌催化的芳烃（包括弱配位芳酮）的直接 C-H 酰胺化反应。

Ruthenium-catalyzed direct C-H amidation of arenes including weakly coordinating aromatic ketones.

机构信息

Center for Catalytic Hydrocarbon Funtionalizations (IBS) and Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

出版信息

Chemistry. 2013 Jun 3;19(23):7328-33. doi: 10.1002/chem.201301025. Epub 2013 Apr 24.

DOI:10.1002/chem.201301025
PMID:23616285
Abstract

C-H activation: The ruthenium-catalyzed direct sp(2) C-H amidation of arenes by using sulfonyl azides as the amino source is presented (see scheme). A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles.

摘要

C-H 活化：本文报道了钌催化的芳基 sp(2) C-H 与磺酰基叠氮直接酰胺化反应（见方案）。该反应使用磺酰基叠氮作为氮源，能够实现多种底物的酰胺化反应，包括具有弱配位基团的芳基。所得到的产物在合成具有生物活性的杂环化合物方面具有潜在的应用价值。

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