School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia.
School of Physics, University of Sydney, New South Wales 2006, Australia; Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia.
Neuroimage. 2018 Nov 1;181:461-470. doi: 10.1016/j.neuroimage.2018.07.031. Epub 2018 Jul 17.
An experimentally tested neural field theory of the corticothalamic system is used to model brain activity and resulting experimental EEG data, and to elucidate the neural mechanisms and physiological basis of alpha-BOLD anticorrelation observed in concurrent EEG and fMRI measurements. Several studies have proposed that the anticorrelation originates from a causal link between changes in the alpha power and BOLD signal. However, the results in this study reveal that fluctuations in alpha and BOLD power do not generate one another but instead respectively result from high- and low-frequency components of the same underlying cortical activity, and that they are inversely correlated via variations in the strengths of corticothalamic and intrathalamic feedback, thereby explaining their anticorrelation.
该研究使用经过实验验证的皮质丘脑系统神经场理论来模拟大脑活动和由此产生的实验 EEG 数据，并阐明在并发 EEG 和 fMRI 测量中观察到的 alpha-BOLD 反相关的神经机制和生理基础。有几项研究提出，这种反相关源自 alpha 功率和 BOLD 信号变化之间的因果关系。然而，本研究的结果表明，alpha 和 BOLD 功率的波动不会相互产生，而是分别来自于相同皮质活动的高频和低频成分，并且通过皮质丘脑和丘脑内反馈强度的变化它们呈负相关，从而解释了它们的反相关。
