Strobel Christine, Quadflieg Norbert, Voderholzer Ulrich, Naab Silke, Fichter Manfred M
Schön Klinik Roseneck Affiliated with the Medical Faculty of the University of Munich (LMU), 83209, Prien, Germany.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Nussbaumstraße 7, 80336, Munich, Germany.
Eat Weight Disord. 2018 Oct;23(5):541-552. doi: 10.1007/s40519-018-0538-6. Epub 2018 Jul 19.
To give an overview of existing studies on the short- and long-term outcome for males treated for anorexia nervosa and to compare the outcome between adolescents and adults as well as between males and females.
A systematic literature search was conducted in PubMed, PsycINFO and PSYNDEX and complemented by a manual search of the references from all relevant studies.
Out of 1064 search results, 18 studies met our inclusion criteria. A combined total of 1129 males of varying age groups were followed 0.5-27 years post-treatment. For 1009 individuals, only vital status was ascertained. Length of follow-up and outcome definitions varied considerably. Limited data-especially in adults-prevented adequate age comparisons. In both adolescents and adults outcome and mortality differed widely across studies with no firm evidence for gender differences. Outcome in mixed samples of adolescents and adults was inconsistent. Studies rarely compared the genders statistically, and when they did, the results were nonsignificant.
Knowledge on the outcome of males treated for anorexia nervosa is scarce. Only few studies comprising insufficient numbers of males exist. Results based on these findings are inconclusive and in part contradicting. Further research is needed, including large sample sizes of reliably diagnosed males, adequate follow-up intervals, follow-up assessments with carefully defined outcome criteria, and comparisons to matched female patient samples.
Level I, Systematic review.
概述现有关于神经性厌食症男性患者短期和长期治疗结果的研究，并比较青少年与成年人以及男性与女性之间的治疗结果。
在PubMed、PsycINFO和PSYNDEX中进行系统的文献检索，并通过手动检索所有相关研究的参考文献进行补充。
在1064条检索结果中，有18项研究符合我们的纳入标准。总共对1129名不同年龄组的男性进行了治疗后0.5至27年的随访。对于1009名个体，仅确定了生存状态。随访时间和结果定义差异很大。有限的数据——尤其是成年人的数据——阻碍了进行充分的年龄比较。在青少年和成年人中，不同研究的结果和死亡率差异很大，没有确凿证据表明存在性别差异。青少年和成年人混合样本的结果不一致。研究很少对性别进行统计学比较，即便进行比较，结果也不显著。
关于神经性厌食症男性患者治疗结果的知识匮乏。仅有少数包含男性数量不足的研究。基于这些发现的结果尚无定论，且部分相互矛盾。需要进一步开展研究，包括纳入大量诊断可靠的男性样本、足够的随访间隔、采用精心定义的结果标准进行随访评估，以及与匹配的女性患者样本进行比较。
一级，系统评价。
