在人类中鉴定出三个新的免疫球蛋白λ样基因。
Identification of three new Ig lambda-like genes in man.
作者信息
Chang H, Dmitrovsky E, Hieter P A, Mitchell K, Leder P, Turoczi L, Kirsch I R, Hollis G F
出版信息
J Exp Med. 1986 Feb 1;163(2):425-35. doi: 10.1084/jem.163.2.425.
Abstract
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
摘要
通过限制性内切酶和核苷酸序列分析鉴定出三个新的人类λ轻链样免疫球蛋白基因。两个基因，即14.1和16.1，具有完整的J区和C区，并且由于具有开放阅读框而具有潜在功能。第三个基因，18.1，是一个假基因。通过Southern印迹和核苷酸同源性可以推测出这些基因与已知的功能性基因座λC1-λC6相比的进化谱系。这项研究表明，人类λ基因家族比以前认识到的更为复杂。
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本文引用的文献
1
Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes.人类κ和λ免疫球蛋白轻链恒定区基因的染色体定位。
J Exp Med. 1982 May 1;155(5):1480-90. doi: 10.1084/jem.155.5.1480.
2
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing.加工后的基因：一个带有RNA类型加工证据的分散人类免疫球蛋白基因。
Nature. 1982 Mar 25;296(5855):321-5. doi: 10.1038/296321a0.
3
Rapid similarity searches of nucleic acid and protein data banks.核酸和蛋白质数据库的快速相似性搜索。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30. doi: 10.1073/pnas.80.3.726.
4
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins.假定的T细胞受体多肽与免疫球蛋白之间的序列关系。
Nature. 1984;308(5955):153-8. doi: 10.1038/308153a0.
5
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.一个人类T细胞特异性cDNA克隆编码一种与免疫球蛋白链具有广泛同源性的蛋白质。
Nature. 1984;308(5955):145-9. doi: 10.1038/308145a0.
6
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7
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J Biol Chem. 1982 Feb 10;257(3):1516-22.
8
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9
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10
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