Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Max Plank Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany; Institute of Molecular Pathology, Campus-Vienna-Biocenter 1, 1030 Vienna, Austria.
Max Plank Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.
Cell. 2018 Jul 26;174(3):607-621.e18. doi: 10.1016/j.cell.2018.06.020. Epub 2018 Jul 19.
Many animals rely on vision to detect, locate, and track moving objects. In Drosophila courtship, males primarily use visual cues to orient toward and follow females and to select the ipsilateral wing for courtship song. Here, we show that the LC10 visual projection neurons convey essential visual information during courtship. Males with LC10 neurons silenced are unable to orient toward or maintain proximity to the female and do not predominantly use the ipsilateral wing when singing. LC10 neurons preferentially respond to small moving objects using an antagonistic motion-based center-surround mechanism. Unilateral activation of LC10 neurons recapitulates the orienting and ipsilateral wing extension normally elicited by females, and the potency with which LC10 induces wing extension is enhanced in a state of courtship arousal controlled by male-specific P1 neurons. These data suggest that LC10 is a major pathway relaying visual input to the courtship circuits in the male brain.
许多动物依赖视觉来检测、定位和跟踪移动物体。在果蝇求偶中，雄性主要使用视觉线索来定位和跟随雌性，并选择同侧翅膀进行求偶鸣叫。在这里，我们表明 LC10 视觉投射神经元在求偶过程中传递重要的视觉信息。沉默 LC10 神经元的雄性无法朝向或接近雌性，并且在唱歌时不主要使用同侧翅膀。LC10 神经元优先使用拮抗运动的基于中心-环绕的机制来响应小的移动物体。单侧激活 LC10 神经元再现了通常由雌性引发的定向和同侧翅膀伸展，并且在由雄性特异性 P1 神经元控制的求偶唤醒状态下，LC10 诱导翅膀伸展的效力增强。这些数据表明 LC10 是将视觉输入传递到雄性大脑求偶回路的主要途径。
