Pavia C S, Baseman J B, Folds J D
Infect Immun. 1977 Feb;15(2):417-22. doi: 10.1128/iai.15.2.417-422.1977.
The in vitro response of peripheral blood lymphocytes from rabbit infected with Treponema pallidum was examined using various mitogens and avirulent Treponema reiteri. For the first 4 weeks after treponemal infection, the response of lymphocytes from syphilitic rabbits to phytohemagglutinin and pokeweed mitogen was markedly reduced in comparison to uninfected controls. Lymphocytes from both groups of rabbits responded normally to class-specific immunoglobulin anti-sera (anti-immunoglobulin M and anti-immunoglobulin G) and T. reiteri.
使用各种促细胞分裂剂和无毒力的回归热密螺旋体,检测感染梅毒螺旋体的家兔外周血淋巴细胞的体外反应。在感染密螺旋体后的前4周,与未感染的对照相比,梅毒家兔淋巴细胞对植物血凝素和商陆促细胞分裂剂的反应明显降低。两组家兔的淋巴细胞对类别特异性免疫球蛋白抗血清(抗免疫球蛋白M和抗免疫球蛋白G)和回归热密螺旋体均有正常反应。