梅毒螺旋体感染的睾丸上清液对正常兔淋巴细胞细胞反应的影响。
Effect of Treponema pallidum-infected testis supernatants on the cellular response of normal rabbit lymphocytes.
作者信息
Wicher K, Wicher V, Kaminski D
出版信息
Infect Immun. 1980 Mar;27(3):846-50. doi: 10.1128/iai.27.3.846-850.1980.
Abstract
This report presents evidence indicating that both Treponema pallidum and the T. pallidum-free supernatant from T. pallidum-infected rabbit testes exert an immunosuppressive effect on the spontaneous proliferation and mitogenic response of normal rabbit lymphocytes. This effect seemed to be on the level of clonal expansion since antigenic recognition and blastogenic factor production occurred in spite of the presence of the immunosuppressive substance(s). The implication of this finding for T. pallidum multiplication in rabbit testes is discussed.
摘要
本报告提供的证据表明，梅毒螺旋体以及来自感染梅毒螺旋体的兔睾丸的无梅毒螺旋体上清液，对正常兔淋巴细胞的自发增殖和有丝分裂原反应均具有免疫抑制作用。这种作用似乎发生在克隆扩增水平，因为尽管存在免疫抑制物质，但仍发生了抗原识别和致有丝分裂因子的产生。本文讨论了这一发现对梅毒螺旋体在兔睾丸中增殖的意义。
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本文引用的文献
1
Hyaluronidase and experimental syphilis. III. Metachromasia in syphilitic orchitis and its relationship to hyaluronic acid.透明质酸酶与实验性梅毒。III. 梅毒性睾丸炎中的异染性及其与透明质酸的关系。
Am J Syph Gonorrhea Vener Dis. 1950 Nov;34(6):501-14.
2
Cortisone in experimental syphilis; a preliminary note.实验性梅毒中的可的松；初步报告。
Bull Johns Hopkins Hosp. 1950 Nov;87(5):505-9.
3
Studies on the mechanism of action of cortisone in experimental syphilis.关于可的松在实验性梅毒中作用机制的研究。
Am J Syph Gonorrhea Vener Dis. 1954 Sep;38(5):371-87.
4
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