一种新的血清淀粉样蛋白A基因的序列与结构。
The sequence and structure of a new serum amyloid A gene.
作者信息
Stearman R S, Lowell C A, Peltzman C G, Morrow J F
出版信息
Nucleic Acids Res. 1986 Jan 24;14(2):797-809. doi: 10.1093/nar/14.2.797.
The acute phase response is characterized by changes in the serum concentrations of many proteins. A 1000-fold increase in the concentration of serum amyloid A (SAA) protein occurs within 24 hours of LPS injection in the mouse. We have isolated a cDNA clone and its corresponding genomic phage for a third, previously unreported SAA protein. The sequence of the cDNA, the gene's exons and neighboring DNA are presented along with the mapping evidence supporting the gene structure.
急性期反应的特征是许多蛋白质的血清浓度发生变化。在小鼠中注射脂多糖后24小时内，血清淀粉样蛋白A（SAA）的浓度会增加1000倍。我们已经分离出一个cDNA克隆及其对应的基因组噬菌体，用于一种之前未报道过的第三种SAA蛋白。文中展示了该cDNA序列、基因的外显子和相邻DNA，以及支持该基因结构的定位证据。
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