• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新的血清淀粉样蛋白A基因的序列与结构。

The sequence and structure of a new serum amyloid A gene.

作者信息

Stearman R S, Lowell C A, Peltzman C G, Morrow J F

出版信息

Nucleic Acids Res. 1986 Jan 24;14(2):797-809. doi: 10.1093/nar/14.2.797.

DOI:10.1093/nar/14.2.797
PMID:3003697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339465/
Abstract

The acute phase response is characterized by changes in the serum concentrations of many proteins. A 1000-fold increase in the concentration of serum amyloid A (SAA) protein occurs within 24 hours of LPS injection in the mouse. We have isolated a cDNA clone and its corresponding genomic phage for a third, previously unreported SAA protein. The sequence of the cDNA, the gene's exons and neighboring DNA are presented along with the mapping evidence supporting the gene structure.

摘要

急性期反应的特征是许多蛋白质的血清浓度发生变化。在小鼠中注射脂多糖后24小时内，血清淀粉样蛋白A（SAA）的浓度会增加1000倍。我们已经分离出一个cDNA克隆及其对应的基因组噬菌体，用于一种之前未报道过的第三种SAA蛋白。文中展示了该cDNA序列、基因的外显子和相邻DNA，以及支持该基因结构的定位证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/50c17c39c072/nar00271-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/e9ab6ff62627/nar00271-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/37087676ec65/nar00271-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/50c17c39c072/nar00271-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/e9ab6ff62627/nar00271-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/37087676ec65/nar00271-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e505/339465/50c17c39c072/nar00271-0189-a.jpg

相似文献

1
The sequence and structure of a new serum amyloid A gene.一种新的血清淀粉样蛋白A基因的序列与结构。
Nucleic Acids Res. 1986 Jan 24;14(2):797-809. doi: 10.1093/nar/14.2.797.
2
Molecular cloning and nucleotide sequence of cDNA for murine senile amyloid protein: nucleotide substitutions found in apolipoprotein A-II cDNA of senescence accelerated mouse (SAM).小鼠衰老相关淀粉样蛋白cDNA的分子克隆及核苷酸序列：在衰老加速小鼠（SAM）的载脂蛋白A-II cDNA中发现的核苷酸替换
Nucleic Acids Res. 1986 Jul 25;14(14):5729-40. doi: 10.1093/nar/14.14.5729.
3
Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA.人血清淀粉样蛋白A（SAA）：前SAA的生物合成及合成后加工以及由互补DNA定义的结构变体
Biochemistry. 1985 Jun 4;24(12):2931-6. doi: 10.1021/bi00333a018.
4
Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences.从cDNA序列推导的两种主要小鼠血清淀粉样蛋白A的完整一级结构。
Proc Natl Acad Sci U S A. 1985 May;82(9):2915-9. doi: 10.1073/pnas.82.9.2915.
5
Molecular cloning of human genes for serum amyloid A.
Gene. 1983 Jan-Feb;21(1-2):19-24. doi: 10.1016/0378-1119(83)90143-9.
6
Expression and sequence analyses of serum amyloid A in the Syrian hamster.叙利亚仓鼠血清淀粉样蛋白A的表达及序列分析
Biochemistry. 1989 May 30;28(11):4785-90. doi: 10.1021/bi00437a040.
7
Structure of the murine serum amyloid A gene family. Gene conversion.小鼠血清淀粉样蛋白A基因家族的结构。基因转换。
J Biol Chem. 1986 Jun 25;261(18):8442-52.
8
Mink serum amyloid A protein. Expression and primary structure based on cDNA sequences.水貂血清淀粉样蛋白A。基于cDNA序列的表达及一级结构。
J Biol Chem. 1990 Jun 15;265(17):10049-54.
9
Diverse gene expression for isotypes of murine serum amyloid A protein during acute phase reaction.急性期反应期间小鼠血清淀粉样蛋白A蛋白同种型的多样基因表达。
Science. 1986 Apr 11;232(4747):227-9. doi: 10.1126/science.3456645.
10
A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2).一种组成型表达的血清淀粉样蛋白A蛋白基因（SAA4）与急性期血清淀粉样蛋白A蛋白基因（SAA2）紧密相连，并与其具有结构相似性。
Genomics. 1993 May;16(2):447-54. doi: 10.1006/geno.1993.1209.

引用本文的文献

1
Thioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins.含硫氧还蛋白结构域5的抑制作用可引发含血清淀粉样蛋白A的高密度脂蛋白。
Biomedicines. 2022 Mar 18;10(3):709. doi: 10.3390/biomedicines10030709.
2
Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.小鼠对致动脉粥样化饮食反应中炎症基因诱导和类核因子κB转录因子激活的遗传控制
J Clin Invest. 1993 Jun;91(6):2572-9. doi: 10.1172/JCI116495.
3
Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency.

本文引用的文献

1
Changes in high density lipoprotein content following endotoxin administration in the mouse. Formation of serum amyloid protein-rich subfractions.内毒素注射后小鼠高密度脂蛋白含量的变化。富含血清淀粉样蛋白亚组分的形成。
J Biol Chem. 1982 Sep 10;257(17):10510-7.
2
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
3
The phenomenon of the acute phase response.急性期反应现象
人急性期血清淀粉样蛋白A（A-SAA）的体外生物合成：mRNA积累、多聚腺苷酸尾缩短及翻译效率的作用
Biochem J. 1993 May 1;291 ( Pt 3)(Pt 3):701-7. doi: 10.1042/bj2910701.
4
Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.小鼠中存在一条介导氧化应激、炎症基因诱导和主动脉脂肪条纹形成的共同通路的遗传学证据。
J Clin Invest. 1994 Aug;94(2):877-84. doi: 10.1172/JCI117409.
5
Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor.细胞因子诱导小鼠血清淀粉样蛋白A3基因，既需要C/EBP家族蛋白，也需要一种新的组成型核因子。
Mol Cell Biol. 1994 Jul;14(7):4475-84. doi: 10.1128/mcb.14.7.4475-4484.1994.
6
Characterization of the inbred CE/J mouse strain as amyloid resistant.近交系CE/J小鼠品系抗淀粉样蛋白特性的研究
Am J Pathol. 1993 Nov;143(5):1480-5.
7
Amyloid A gene family expression in different mouse tissues.不同小鼠组织中淀粉样蛋白A基因家族的表达。
J Exp Med. 1986 Dec 1;164(6):2006-17. doi: 10.1084/jem.164.6.2006.
8
Identification of three isoform patterns of human serum amyloid A protein.人血清淀粉样蛋白A蛋白三种异构体模式的鉴定
Biochem J. 1988 Feb 15;250(1):203-7. doi: 10.1042/bj2500203.
9
Circular-dichroism studies on two murine serum amyloid A proteins.两种小鼠血清淀粉样蛋白A的圆二色性研究
Biochem J. 1988 Dec 15;256(3):775-83. doi: 10.1042/bj2560775.
10
Regulation of amyloid A gene expression in cultured cells.培养细胞中淀粉样蛋白A基因表达的调控
Mol Cell Biol. 1988 Sep;8(9):3710-6. doi: 10.1128/mcb.8.9.3710-3716.1988.
Ann N Y Acad Sci. 1982;389:39-48. doi: 10.1111/j.1749-6632.1982.tb22124.x.
4
Induction of hepatic synthesis of serum amyloid A protein and actin.诱导肝脏合成血清淀粉样蛋白A和肌动蛋白。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4718-22. doi: 10.1073/pnas.78.8.4718.
5
DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.腺病毒基因在可溶性全细胞提取物中的DNA依赖性转录。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):3855-9. doi: 10.1073/pnas.77.7.3855.
6
Synthesis and regulation of acute phase plasma proteins in primary cultures of mouse hepatocytes.小鼠肝细胞原代培养物中急性期血浆蛋白的合成与调节
J Cell Biol. 1983 Sep;97(3):866-76. doi: 10.1083/jcb.97.3.866.
7
Vitellogenin in Drosophila melanogaster: a comparison of the YPI and YPII genes and their transcription products.黑腹果蝇中的卵黄原蛋白：YPI和YPII基因及其转录产物的比较
Nucleic Acids Res. 1982 Apr 10;10(7):2261-74. doi: 10.1093/nar/10.7.2261.
8
Murine tissue amyloid protein AA. NH2-terminal sequence identity with only one of two serum amyloid protein (ApoSAA) gene products.小鼠组织淀粉样蛋白AA。与两种血清淀粉样蛋白（ApoSAA）基因产物之一仅在氨基末端具有序列同一性。
J Exp Med. 1984 Feb 1;159(2):641-6. doi: 10.1084/jem.159.2.641.
9
A practical approach for quantitating specific mRNAs by solution hybridization.一种通过溶液杂交对特定信使核糖核酸进行定量的实用方法。
Anal Biochem. 1983 Jun;131(2):385-93. doi: 10.1016/0003-2697(83)90188-4.
10
Repeated DNA sequences near the 5'-end of the silk fibroin gene.丝素蛋白基因5'-端附近的重复DNA序列。
J Biol Chem. 1981 Apr 25;256(8):4033-41.